Borhane Annabi

Département de chimie

Faculté : Faculté des sciences

Poste de professeur : Professeur

Courriel : annabi.borhane@uqam.ca

Téléphone : (514) 987-3000 poste 7610

Local : CB-4150

Domaines d'expertises

  • Tumeurs cérébrales
  • Angiogenèse tumorale
  • Cellules souches stromales et cancéreuses
  • Biochimie


  • Français
  • Anglais
  • Information générale
  • Cours
  • Publications
  • Communications
  • Réalisations
  • Prix et distinctions

Liens d’intérêt

Unités de recherche

    Centre de recherches biomédicales (BIOMED) Chaire en prévention et traitement du cancer

Projets de recherche en cours

  • Metabolic and tumorigenic adaptation in mesenchymal stromal cells (CRSNG)

Partenaires (organismes, entreprises)


Affiliations externes principales

  • Université de Montréal, Département de Physiologie (Professeur associé)
  • Réseau de Thérapie Cellulaire et Tissulaire ThéCELL (membre)
  • Groupe d'étude des protéines membranaires GÉPROM, Université de Montréal (Membre associé)

Prix et distinctions

  • Chaire de Recherche du Canada en Oncologie Moléculaire (Tiers-2, 2002-2006)
  • Chaire de Recherche du Canada en Oncologie Moléculaire (Tiers-2, 2007-2012)


  • Chapitre de livre

    ANNABI B. (2009) Les cellules souches cancéreuses Le Guide des Tendances 2009 collection GuidesIQ, ««Isabelle Quentin Editeur, vol(1), pp98-100

  • Articles scientifiques

    [79] Zgheib A, Pelletier-Bonnier E, Levros Jr LC & ANNABI B. (2013) Selective JAK/STAT3 signalling regulates colony stimulating factor-2 and -3 transcription in Concanavalin-A-activated mesenchymal stromal cells Cytokine 63(2):187-193

    [78] Zgheib A, Lamy S & ANNABI B. (2013) Epigallocatechin-gallate targeting of membrane type-1 matrix metalloproteinase-mediated Src and JAK/STAT3 signalling inhibits transcription of colony stimulating factors-2 and -3 in mesenchymal stromal cells Journal of Biological Chemistry 288(19):13378-13386

    [77] ANNABI B., Vaillancourt-Jean, E., Béliveau R. (2013) MT1-MMP expression level status dictates the in vitro action of lupeol on inflammatory biomarkers MMP-9 and COX-2 in medulloblastoma cells Inflammopharmacology 21(1):91-99

    [76] Pratt J., Roy R. & ANNABI B. (2012) Membrane type-1 matrix metalloproteinase intracellular signalling regulates lectin-induced autophagy in glioblastoma cells Glycobiology 22(9):1245-1255

    [75] Akla N., Pratt J. & ANNABI B. (2012) Concanavalin-A triggers inflammatory response through JAK/STAT3 signalling and modulates MT1-MMP regulation of COX-2 in mesenchymal stromal cells Experimental Cell Research 318(19):2498-2506

    [74] Vézina A., Chokor R. & ANNABI B. (2012) EGCG targeting efficacy of NF-¿B downstream gene products is dictated by the monocytic/macrophagic differentiation status of promyelocytic leukemia cells Cancer Immunology and Immunotherapy (in press)

    [73] ANNABI B., Lord-Dufour S., Vézina A. & Béliveau R (2012) Resveratrol targeting of carcinogen-induced brain endothelial cell inflammation biomarkers MMP-9 and COX-2 is Sirt1-independent Drug Target Insights 6:1-11

    [72] Sartelet H., Imbriglio T., Nyalendo C., Haddad E., ANNABI B., Duval M., Fetni R., Victor K., Alexendrov L., Sinnett D., Fabre M., Vassal G. (2012) CD133 expression associated with poor outcome in neuroblastoma via chemoresistance mediated by the AKT pathway Histopathology 60:1144-1155

    [71] Proulx-Bonneau S. & ANNABI B. (2011) The primary cilium as a biomarker in the hypoxic adaptation of bone marrow-derived mesenchymal stromal cells : A role for the secreted Frizzeled-Related Proteins Biomarker Insights 6:107-118

    [70] Proulx-Bonneau S., Pratt J. & ANNABI B. (2011) A role for MT1-MMP as a cell death sensor/effector through the regulation of endoplasmic reticulum stress in glioblastoma cells Journal of Neurooncology 104(1):33-43

    [69] Proulx-Bonneau S., Guezguez A. & ANNABI B. (2011) A concerted MT1-MMP/HIF-1¿ signalling is required for induction of adaptor protein 3BP2/SH3BP2 in mesenchymal stromal cells PLoS ONE 6(6):e21511

    [68] Tahanian T., Arguello-Sanchez L., Shiao TC., Roy R. & ANNABI B. (2011) Targeting of I¿B phosphorylation by flavonoids abrogates MMP-9 and COX-2 expression in human brain endothelial cells. Drug Design, Development and Therapy 5:299-309

    [67] Tahanian E., Peiro S. & ANNABI B. (2011) Low intracellular ATP levels exacerbate carcinogen-induced inflammatory stress response and inhibit in vitro tubulogenesis in human brain endothelial cells Journal of Inflammation Research 4(1):1-10

    [66] Sina A., Lord-Dufour S., Roy R., & ANNABI B. (2011) Ciblage pharmacologique de la MT1-MMP dans les cellules tumorales cérébrales par l'actinonine, un inhibiteur de l'aminopeptidase N/CD13 BioTribune Magazine 38-39(1):12-18

    [65] Kuss S., Cornut R., Beaulieu I., Mezour M.A., ANNABI B. & Mauzeroll J. (2011) Assessing multidrug resistance protein 1-mediated function in cancer cell multidrug resistance by scanning electrochemical microscopy and flow cytometry Bioelectrochemistry 82(1):29-37

    [64] Tahanian E., Lord-Dufour S., Das A., Khosla C., Roy R., & ANNABI B. (2010) Inhibition of tubulogenesis and carcinogen-induced MMP-9 secretion in human brain endothelial cells highlight antiangiogenic properties of mumbastatin analogs Chemical Biology and Drug Design 75(5):481-488

    [63] Sina A., Proulx-Bonneau S., Roy A., Poliquin L., Cao J. & ANNABI B. (2010) The lectin concanavalin-A signals MT1-MMP catalytic independent induction of COX-2 through an IKK¿/NF-¿B-dependent pathway Journal of Cell Communication and Signaling 4(1):31-38

    [62] ANNABI B., Vaillancourt-Jean E., Weil AG. & Béliveau R. (2010) Pharmacological targeting of ¿¿adrenergic receptor functions abrogates carcinogen-mediated MMP-9 secretion through NF-¿B signalling in medulloblastoma cells OncoTargets and Therapy 3:219-226

    [61] ANNABI B., Doumit J., Plouffe K., Laflamme C., Lord-Dufour S. & Béliveau R. (2010) Members of the low density lipoprotein receptor-related-proteins provide a differential molecular signature between parental and CD133(+) DAOY medulloblastoma cells Molecular Carcinogenesis 49(7):710-717

    [60] Lord-Dufour S., Copland IB., Levros LC., Post M., Das A., Khosla C., Galipeau J., Rassart E. & ANNABI B. (2009) Evidence for transcriptional regulation of the glucose-6-phosphate transporter by HIF-1alpha: Targeting G6PT with mumbaistatin analogs in hypoxic mesenchymal stromal cells Stem Cells 27(3):489-497

    [59] Sina A., Lord-Dufour S. & ANNABI B. (2009) Cell-based evidence for aminopeptidase N/CD13 inhibitor actinonin targeting of MT1-MMP-mediated proMMP-2 activation Cancer Letters 279(2):171-176

    [58] ANNABI B. Lachambre MP., Plouffe K., Sartelet H. & Béliveau R. (2009) Modulation of invasive properties of CD133(+) glioblastoma stem cells : A role for MT1-MMP in bioactive lysophospholipid signaling Molecular Carcinogenesis 48(10):910-919

    [57] ANNABI B., Lachambre MP., Plouffe K., Moumdjian R. & Béliveau R. (2009) Propranolol adrenergic blockade inhibits human brain endothelial cells tubulogenesis and matrix metalloproteinase-9 secretion Pharmacological Research 60(5):438-445

    [56] ANNABI B., Laflamme C., Sina A., Lachambre MP., Béliveau R. (2009) A MT1-MMP/NF-¿B signaling axis as a checkpoint controller of COX-2 expression in CD133(+) U87 glioblastoma cells Journal of Neuroinflammation 6(1):8-18

    [55] Copland IB., Lord-Dufour S., Cuerquis J., Legault-Coutu D., ANNABI B., Wang E. & Galipeau J. (2009) Improved autograft survival of mesenchymal stromal cells by plasminogen activator inhibitor 1 inhibition Stem Cells 27(2):467-477

    [54] Fortier S., Labelle D., Sina A., Moreau R. & ANNABI B. (2008) Silencing of the MT1-MMP / G6PT axis suppresses calcium mobilization by sphingosine-1-phosphate in glioblastoma cells FEBS Letters 582(5):799-804

    [53] Fortier S., Touaibia M., Lord-Dufour S., Galipeau J., Roy R. & ANNABI B. (2008) Tetra- and hexavalent mannosides inhibit the pro-apoptotic, anti-proliferative and cell surface clustering effects of concanavalin-A : Impact on MT1-MMP functions in marrow-derived mesenchymal stromal cells Glycobiology 18(2):195-204

    [52] ANNABI B., Rojas-Sutterlin S., Laflamme C., Lachambre MP., Rolland Y., Sartelet H. & Béliveau R. (2008) Tumour tissue environment dictates CD133(+) medulloblastoma-derived cancer stem cells expression and invasive phenotype : A role for MT1-MMP and MMP-9 Molecular Cancer Research 6(6):907-916

    [51] ANNABI B., Rojas-Sutterlin S., Laroche M., Lachambre MP., Moumdjian R. & Béliveau R. (2008) The diet-derived sulforaphane inhibits matrix metalloproteinase-9-activated human brain microvascular endothelial cell migration and tubulogenesis. Molecular Nutrition and Food Research 52(6):692-700

    [50] Copland IB., Jolicoeur ME., Gillis MA., Cuerquis J., Eliopoulos N., ANNABI B., Calderone A., Tanguay JF., Ducharme A. & Galipeau J. (2008) Coupling erythropoietin secretion to mesenchymal stromal cells enhances their regenerative properties. Cardiovascular Research 79(3):405-415

    [49] Rafei M., Hiseh J., Fortier S., Li M, Yuan S., Birman E., Forner K., Boivin MN., Doody K, Tremblay M., ANNABI B. & Galipeau J. (2008) Mesenchymal stromal cell generation of MMP-cleaved antagonistic CCL2 suppresses immunoglobulin production via STAT3 activation and PAX5 induction in antigen-activated plasma cells Blood 112(13):4991-4998

    [48] Currie JC., Fortier S., Sina A., Galipeau J., Cao J. & ANNABI B. (2007) MT1-MMP downregulates the glucose-6-phosphate transporter expression in marrow stromal cells : A molecular link between proMMP-2 activation, chemotaxis and cell survival. Journal of Biological Chemistry 282(11):8142-8149

    [47] Belkaid A., Fortier S., Cao J. & ANNABI B. (2007) Necrosis induction in glioblastoma cells reveals a new ¿bio-switch¿ function for the MT1-MMP/G6PT signalling axis in proMMP-2 activation versus death cell decision Neoplasia 9(4):332-340

    [46] ANNABI B., Currie JC., Moghrabi A. & Béliveau R. (2007) Inhibition of HuR and MMP-9 expression in macrophage-differentiated HL-60 myeloid leukemia cells by green tea polyphenol EGCg Leukemia Research 31(9):1285-1292

    [45] Perri SR., ANNABI B. & Galipeau J. (2007) Angiostatin inhibits monocyte/macrophage migration via disruption of actin cytoskeleton. FASEB Journal 21(14):3928-3936

    [44] Rafei M., Wu JH., ANNABI B., Lejeune L., François M. & Galipeau J. (2007) A GMCSF & IL15 fusokine leads to paradoxical immunosuppression in vivo via asymmetrical JAK/STAT signaling through the IL15 receptor complex Blood 109(5):2234-2242

    [43] Ngameni B., Touaibia M., Belkaid A.*, Ambassa P., Watchueng J., Patnam R., Ngadjui BT., ANNABI B. & Roy R. (2007) Inhibition of matrix metalloproteinase-2 secretion by chalcones from the twigs of Dorstenia barteri Bureau ARKIVOC - Archive for Organic Chemistry 9:91-103



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