Borhane Annabi

Département de chimie

Faculté : Faculté des sciences

Poste : Professeur

Courriel : annabi.borhane@uqam.ca

Téléphone : (514) 987-3000 poste 7610

Local : CB-4150

Domaines d'expertises

  • Tumeurs cérébrales
  • Angiogenèse tumorale
  • Cellules souches stromales et cancéreuses
  • Biochimie

Langues

  • Français
  • Anglais
  • Général
  • Enseignement et supervision
  • Publications
  • Communications
  • Réalisations
  • Distinctions
  • Services à la collectivité

Cheminement académique

1999-2001 Stage Post-Doctoral en Cancérologie
Sainte-Justine Pediatric Hospital Research Centre (Montreal, Canada)
"Pathophysiology and molecular regulation of MT1-MMP in tumor angiogenesis"


1997-1998 Stage Post-Doctoral en Génétique
National Institute of Child Health and Human Development (Bethesda, USA)
"Molecular genetics of the heritable Glycogen Storage Disease type 1"


1997 Doctorat en Biochimie
Metabolic Endocrinology Laboratory, Université de Montréal
"Transport and hydrolytic functions of the liver microsomal glucose-6-phosphatase system"


1994 Maitrise en Biochimie
Metabolic Endocrinology Laboratory, Université de Montréal
"Defects in the hepatic glycogen metabolism : Etiological study in the genetically obese (fa/fa) Zucker rat"


1990 Baccalauréat en Biochimie
Université de Montréal

Liens d’intérêt

Unités de recherche

  • Centre de recherches biomédicales (BIOMED)
  • Chaire en prévention et traitement du cancer

Projets de recherche en cours

  • Metabolic and tumorigenic adaptation in mesenchymal stromal cells (CRSNG-SD)

  • Probing into low-density lipoprotein receptor-related protein (LRP)-1-independent peptide transcytosis mechanisms (CRSNG-RDC)

Partenaires (organismes, entreprises)

  • CRSNG-SD / CRSNG-RDC / FQRNT / FCI

Affiliations externes principales

  • Université de Montréal, Département de Physiologie (Professeur associé)
  • Réseau de Thérapie Cellulaire et Tissulaire ThéCELL (membre)
  • Groupe d'étude des protéines membranaires GÉPROM, Université de Montréal (Membre associé)

Prix et distinctions

  • Chaire de Recherche du Canada en Oncologie Moléculaire (Tiers-2, 2002-2006)
  • Chaire de Recherche du Canada en Oncologie Moléculaire (Tiers-2, 2007-2012)

Publications

Lamy, S., Moldovan, P.L., Ben Saad, A. et Annabi, B. (2015). Biphasic effects of luteolin on interleukin-1β-induced cyclooxygenase-2 expression in glioblastoma cells. Biochimica et Biophysica Acta – Molecular Cell Research, 1853(1), 126–135. http://dx.doi.org/10.1016/j.bbamcr.2014.10.010.

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Chokor, R., Lamy, S. et Annabi, B. (2014). Transcriptional targeting of sphingosine-1- phosphate receptor S1P2 by epigallocatechin- 3-gallate prevents sphingosine-1-phosphate- mediated signaling in macrophage-differentiated HL -60 promyelomonocytic leukemia cells. OncoTargets and Therapy, 7, 667–677. http://dx.doi.org/10.2147/OTT.S62717.

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Regina, A., Demeule, M., Tripathy, S., et al. (2014). ANG4043, a novel brain penetrant anti-HER2 mAb conjugate is efficacious against HER2-positive intracranial tumors in mice. Molecular Cancer Therapeutics.
Notes: In press

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Gupta, R., Toufaily, C. et Annabi, B. (2014). Caveolin and cavin family members: Dual roles in cancer. Biochimie. http://dx.doi.org/10.1016/j.biochi.2014.09.010.

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Pratt, J. et Annabi, B. (2014). Induction of autophagy biomarker BNIP3 requires a JAK2/STAT3 and MT1-MMP signaling interplay in Concanavalin-A-activated U87 glioblastoma cells. Cellular Signalling, 26(5), 917–924. http://dx.doi.org/10.1016/j.cellsig.2014.01.012.

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Desjarlais, M., Pratt, J., Lounis, A., Mounier, C., Haidara, K. et Annabi, B. (2014). Tetracycline derivative minocycline inhibits autophagy and inflammation in concanavalin-A-activated human hepatoma cells. Gene Regulation and Systems Biology, 2014(8), 63–73. http://dx.doi.org/10.4137/GRSB.S13946.

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Zgheib, A., Pelletier-Bonnier, E., Levros, L.C. et Annabi, B. (2013). Selective JAK/STAT3 signalling regulates transcription of colony stimulating factor-2 and-3 in Concanavalin-A-activated mesenchymal stromal cells. Cytokine, 63(2), 187–193. http://dx.doi.org/10.1016/j.cyto.2013.04.027.

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Annabi, B., Vaillancourt-Jean, E. et Béliveau, R. (2013). MT1-MMP expression level status dictates the in vitro action of lupeol on inflammatory biomarkers MMP-9 and COX-2 in medulloblastoma cells. Inflammopharmacology, 21(1), 91–99.

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Zgheib, A., Lamy, S. et Annabi, B. (2013). Epigallocatechin gallate targeting of membrane type 1 matrix metalloproteinase-mediated src and janus kinase/signal transducers and activators of transcription 3 signaling inhibits transcription of colony-stimulating factors 2 and 3 in mesenchymal stromal cells. Journal of Biological Chemistry, 288(19), 13378–13386. http://dx.doi.org/10.1074/jbc.M113.456533.

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Sartelet, H., Imbriglio, T., Nyalendo, C., et al. (2012). CD133 expression is associated with poor outcome in neuroblastoma via chemoresistance mediated by the AKT pathway. Histopathology, 60(7), 1144–1155. http://dx.doi.org/10.1111/j.1365-2559.2012.04191.x.

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Annabi, B., Lord-Dufour, S., Vézina, A. et Béliveau, R. (2012). Resveratrol targeting of carcinogen-induced brain endothelial cell inflammation biomarkers MMP-9 and COX-2 is sirt1-independent. Drug Target Insights, 6, 1–11. http://dx.doi.org/10.4137/DTI.S9442.

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Pratt, J., Roy, R. et Annabi, B. (2012). Concanavalin-A-induced autophagy biomarkers requires membrane type-1 matrix metalloproteinase intracellular signaling in glioblastoma cells. Glycobiology, 22(9), 1245–1255. http://dx.doi.org/10.1093/glycob/cws093.

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Annabi, B., Pratt J. et Roy, R. (2012). Membrane type-1 matrix metalloproteinase intracellular signalling regulates lectin-induced autophagy in glioblastoma cells Glycobiology. Glycobiology, 22(9), 1245–1255.

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Akla, N., Pratt, J. et Annabi, B. (2012). Concanavalin-A triggers inflammatory response through JAK/STAT3 signalling and modulates MT1-MMP regulation of COX-2 in mesenchymal stromal cells. Experimental Cell Research, 318(19), 2498–2506. http://dx.doi.org/10.1016/j.yexcr.2012.08.003.

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Annabi, B., Vaillancourt-Jean, E. et Béliveau, R. (2012). MT1-MMP expression level status dictates the in vitro action of lupeol on inflammatory biomarkers MMP-9 and COX-2 in medulloblastoma cells. Inflammopharmacology, 1–9. http://dx.doi.org/10.1007/s10787-012-0142-8.

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Vezina, A., Chokor, R. et Annabi, B. (2012). EGCG targeting efficacy of NF-kappa B downstream gene products is dictated by the monocytic/macrophagic differentiation status of promyelocytic leukemia cells. Cancer Immunology Immunotherapy, 61(12), 2321–2331. http://dx.doi.org/10.1007/s00262-012-1301-x.

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Kuss, S., Cornut, R., Beaulieu, I., Mezour, M.A., Annabi, B. et Mauzeroll, J. (2011). Assessing multidrug resistance protein 1-mediated function in cancer cell multidrug resistance by scanning electrochemical microscopy and flow cytometry. Bioelectrochemistry, 82(1), 29–37. http://dx.doi.org/10.1016/j.bioelechem.2011.04.008.

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Tahanian, E., Sanchez, L.A., Shiao, T.C., Roy, R. et Annabi, B. (2011). Flavonoids targeting of I kappa B phosphorylation abrogates carcinogen-induced MMP-9 and COX-2 expression in human brain endothelial cells. Drug Design Development and Therapy, 5, 299–309. http://dx.doi.org/10.2147/DDDT.S19931.

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Proulx-Bonneau, S., Guezguez, A. et Annabi, B. (2011). A Concerted HIF-1α/MT1-MMP Signalling Axis Regulates the Expression of the 3BP2 Adaptor Protein in Hypoxic Mesenchymal Stromal Cells. PLoS ONE, 6(6), e21511EP–. http://dx.doi.org/10.1371/journal.pone.0021511.

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Annabi, B., Tahanian, E., et Peiro, S. (2011). Low intracellular ATP levels exacerbate carcinogen-induced inflammatory stress response and inhibit in vitro tubulogenesis in human brain endothelial cells. Journal of Inflammation Research, 4(1), 1–10.

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Proulx-Bonneau, S. et Annabi, B. (2011). The primary cilium as a biomarker in the hypoxic adaptation of bone marrow-derived mesenchymal stromal cells: A role for the secreted frizzled-related proteins. Biomarker Insights, 6, 107–118. http://dx.doi.org/10.4137/BMI.S8247.

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Sina, A., Lord-Dufour, S., Roy, R. et Annabi, B. (2011). Ciblage pharmacologique de la MT1-MMP dans les cellules tumorales cérébrales par l'actinonine, un inhibiteur de l'aminopeptidase N/CD13. Bio Tribune Magazine, 38(1), 39–45. http://dx.doi.org/10.1007/s11834-011-0042-z.

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Annabi, B., Tahanian, T., Arguello-Sanchez, L., Shiao, T.C. et Roy, R. (2011). Targeting of I¿B phosphorylation by flavonoids abrogates MMP-9 and COX-2 expression in human brain endothelial cells. Drug Design, Development and Therapy, (5), 299–309.

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Annabi, B., Proulx-Bonneau, S. et Pratt, J. (2011). A role for MT1-MMP as a cell death sensor/effector through the regulation of endoplasmic reticulum stress in glioblastoma cells. Journal of Neurooncology, 104(1), 33–43.

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Annabi, B., A, S., Lord-Dufour, S. et R, R. (2011). Ciblage pharmacologique de la MT1-MMP dans les cellules tumorales cérébrales par l'actinonine, un inhibiteur de l'aminopeptidase N/CD13. BioTribune Magazine, 38-39(1), 12–18.

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Annabi, B., Proulx-Bonneau, S. et Guezguez, A. (2011). A concerted MT1-MMP/HIF-1¿ signalling is required for induction of adaptor protein 3BP2/SH3BP2 in mesenchymal stromal cells PLoS ONE. PLoS ONE, 6(6), e21511.

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Annabi, B., Doumit, J., Plouffe, K., Laflamme, C., Lord-Dufour, S. et Béliveau, R. (2010). Members of the low-density lipoprotein receptor-related proteins provide a differential molecular signature between parental and CD133(+) DAOY medulloblastoma cells. Molecular Carcinogenesis, 49(7), 710–717. http://dx.doi.org/10.1002/mc.20645.

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Annabi, B., E, V.-J.,, Weil, A.G. et R, B. (2010). Pharmacological targeting of ¿¿adrenergic receptor functions abrogates carcinogen-mediated MMP-9 secretion through NF-¿B signalling in medulloblastoma cells OncoTargets and Therapy. OncoTargets and Therapy, 49(7), 710–717.

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Tahanian, E., Lord‐dufour, S., Das, A., Khosla, C., Roy, R. et Annabi, B. (2010). Inhibition of Tubulogenesis and of Carcinogen‐mediated Signaling in Brain Endothelial Cells Highlight the Antiangiogenic Properties of a Mumbaistatin Analog. Chemical Biology & Drug Design, 75(5), 481–488. http://dx.doi.org/10.1111/j.1747-0285.2010.00961.x.

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Sina, A., Proulx-Bonneau, S., Roy, A., Poliquin, L., Cao, J. et Annabi, B. (2010). The lectin concanavalin-A signals MT1-MMP catalytic independent induction of COX-2 through an IKKγ/NF-κB-dependent pathway. Journal of Cell Communication and Signaling, 4(1), 31–38. http://dx.doi.org/10.1007/s12079-009-0084-0.

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Annabi, B., Laflamme, C., Sina, A., Lachambre, M.P. et Beliveau, R. (2009). A MT1-MMP/NF-kappa B signaling axis as a checkpoint controller of COX-2 expression in CD133(+) U87 glioblastoma cells. Journal of Neuroinflammation, 6(1), 8–18. http://dx.doi.org/10.1186/1742-2094-6-8.

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Annabi, B., A, S. et Lord-Dufour, S. (2009). Cell-based evidence for aminopeptidase N/CD13 inhibitor actinonin targeting of MT1-MMP-mediated proMMP-2 activation. Cancer Letters, 279(2), 171–179.

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Annabi, B., Lachambre, M.-P., Plouffe, K., Moumdjian, R. et Béliveau, R. (2009). Propranolol adrenergic blockade inhibits human brain endothelial cells tubulogenesis and matrix metalloproteinase-9 secretion. Pharmacological Research, 60(5), 438–445. http://dx.doi.org/10.1016/j.phrs.2009.05.005.

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Lord-Dufour, S., Copland, I.B., Levros, L.C., et al. (2009). Evidence for Transcriptional Regulation of the Glucose-6-Phosphate Transporter by HIF-1 alpha: Targeting G6PT with Mumbaistatin Analogs in Hypoxic Mesenchymal Stromal Cells. Stem cells, 27(3), 489–497. http://dx.doi.org/10.1634/stemcells.2008-0855.

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Annabi, B., Lachambre, M.-P., Plouffe, K., Sartelet, H. et Béliveau, R. (2009). Modulation of invasive properties of CD133(+) glioblastoma stem cells: A role for MT1-MMP in bioactive lysophospholipid signaling. Molecular Carcinogenesis, 48(10), 910–919. http://dx.doi.org/10.1002/mc.20541.

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Copland, I.B., Lord-Dufour, S., Cuerquis, J., et al. (2009). Improved Autograft Survival of Mesenchymal Stromal Cells by Plasminogen Activator Inhibitor 1 Inhibition. Stem Cells, 27(2), 467–477. http://dx.doi.org/10.1634/stemcells.2008-0520.

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Fortier, S., Labelle, D., Sina, A., Moreau, R. et Annabi, B. (2008). Silencing of the MT1-MMP/ G6PT axis suppresses calcium mobilization by sphingosine-1-phosphate in glioblastoma cells. FEBS Letters, 582(5), 799–804. http://dx.doi.org/10.1016/j.febslet.2008.01.061.

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Annabi, B., Rojas-Sutterlin, S., Laflamme, C., et al. (2008). Tumor Environment Dictates Medulloblastoma Cancer Stem Cell Expression and Invasive Phenotype. Molecular Cancer Research, 6(6), 907–916. Récupéré de http://mcr.aacrjournals.org/content/6/6/907.abstract.

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Annabi, B., Rojas-Sutterlin, S., Laroche, M., Lacharnbre, M.P., Moumdjian, R. et Beliveau, R. (2008). The diet-derived sulforaphane inhibits matrix metalloproteinase-9-activated human brain microvascular endothelial cell migration and tubulogenesis. Molecular Nutrition and Food Research, 52(6), 692–700. http://dx.doi.org/10.1002/mnfr.200700434.

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Annabi, B., Fortier, S., Touaibia, M., Lord-Dufour, S., Galipeau, J. et Roy, R. (2008). Tetra- and hexavalent mannosides inhibit the pro-apoptotic, anti-proliferative and cell surface clustering effects of concanavalin-A : Impact on MT1-MMP functions in marrow-derived mesenchymal stromal cells Glycobiology. Glycobiology, 18(2), 195–204.

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Rafei, M., Hsieh, J., Fortier, S., et al. (2008). Mesenchymal stromal cell-derived CCL2 suppresses plasma cell immunoglobulin production via STAT3 inactivation and PAX5 induction. Blood, 112(13), 4991–4998. http://dx.doi.org/10.1182/blood-2008-07-166892.

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Annabi, B., Copland, I.B., Jolicoeur, M.E., et al. (2008). Coupling erythropoietin secretion to mesenchymal stromal cells enhances their regenerative properties. Cardiovascular Research, 79(3), 405–415.

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Ngameni, B., Touaibia, M., Belkaid, A., et al. (2007). Inhibition of matrix metalloproteinase-2 secretion by chalcones from the twigs of Dorstenia barteri Bureau. ARKIVOC – Archive for Organic Chemistry, 9, 91–103.

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Belkaid, A., Fortier, S., Cao, J. et Annabi, B. (2007). Necrosis induction in glioblastoma cells reveals a new "bioswitch'' function for the MT1-MMP/G6PT signaling axis in proMMP-2 activation versus cell death decision. Neoplasia, 9(4), 332–340. http://dx.doi.org/10.1593/neo.07142.

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Annabi, B., Currie, J.C., Moghrabi, A. et Béliveau, R. (2007). Inhibition of HuR and MMP-9 expression in macrophage-differentiated HL-60 myeloid leukemia cells by green tea polyphenol EGCg Leukemia Research. Leukemia Research, 31(9), 1285–1292.

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Annabi, B., Currie, J.C., Moghrabi, A. et Beliveau, R. (2007). Inhibition of HuR and MMP-9 expression in macrophage-differentiated HL-60 myeloid leukemia cells by green tea polyphenol EGCg. Leukemia Research, 31(9), 1277–1284. http://dx.doi.org/10.1016/j.leukres.2006.10.001.

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Annabi, B., Perri, S.R. et Galipeau, J. (2007). Angiostatin inhibits monocyte/macrophage migration via disruption of actin cytoskeleton. FASEB Journal, 21(14), 3928–3936.

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Currie, J.-C., Fortier, S., Sina, A., Galipeau, J., Cao, J. et Annabi, B. (2007). MT1-MMP down-regulates the glucose 6-phosphate transporter expression in marrow stromal cells: A molecular link between pro-MMP-2 activation, chemotaxis, and cell survival. Journal of Biological Chemistry, 282(11), 8142–8149. http://dx.doi.org/10.1074/jbc.M610894200.

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Annabi, B., Currie, J.-C., Bouzeghrane, M., et al. (2006). Contribution of the 37-kDa laminin receptor precursor in the anti-metastatic PSP94-derived peptide PCK3145 cell surface binding. Biochemical and Biophysical Research Communications, 346(1), 358–366. http://dx.doi.org/10.1016/j.bbrc.2006.05.139.

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Lamy, S., Ruiz, M.T., Wisniewski, J., et al. (2006). A prostate secretory protein94-derived synthetic peptide PCK3145 inhibits VEGF signalling in endothelial cells: Implication in tumor angiogenesis. International Journal of Cancer, 118(9), 2350–2358. http://dx.doi.org/10.1002/ijc.21615.

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Belkaid, A., Copland, I.B., Massillon, D. et Annabi, B. (2006). Silencing of the human microsomal glucose-6-phosphate translocase induces glioma cell death: Potential new anticancer target for curcumin. FEBS Letters, 580(15), 3746–3752. http://dx.doi.org/10.1016/j.febslet.2006.05.071.

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McLaughlin, N., Annabi, B., Bouzeghrane, M., et al. (2006). The Survivin-mediated radioresistant phenotype of glioblastomas is regulated by RhoA and inhibited by the green tea polyphenol (-)-epigallocatechin-3-gallate. Brain Research, 1071(1), 1–9. http://dx.doi.org/10.1016/j.brainres.2005.10.009.

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McLaughlin, N., Annabi, B., Kim, K.S., Bahary, J.-P., Moumdjian, R. et Béliveau, R. (2006). The response to brain tumor-derived growth factors is altered in radioresistant human brain endothelial cells. Cancer Biology & Therapy, 5(11), 1539–1545. http://dx.doi.org/10.4161/cbt.5.11.3459.

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Belkaid, A., Currie, J.C., Desgagnes, J. et Annabi, B. (2006). The chemopreventive properties of chlorogenic acid reveal a potential new role for the microsomal glucose-6-phosphate translocase in brain tumor progression. Cancer Cell International, 6(1), 7. http://dx.doi.org/10.1186/1475-2867-6-7.

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McLaughlin, N., Annabi, B., Lachambre, M.-P., et al. (2006). Combined low dose ionizing radiation and green tea-derived epigallocatechin-3-gallate treatment induces human brain endothelial cells death. Journal of Neuro-Oncology, 80(2), 111–121. http://dx.doi.org/10.1007/s11060-006-9171-8.

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Rafei, M., Wu, J.H., Annabi, B., Lejeune, L., Francois, M. et Galipeau, J. (2006). A GMCSF & IL15 fusokine leads to paradoxical immunosuppression in vivo via asymmetrical JAK/STAT signalling through the IL15 receptor complex. Blood, 108(11), 910A.

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Meriane, M., Duhamel, S., Lejeune, L., Galipeau, J. et Annabi, B. (2006). Cooperation of matrix metalloproteinases with the RhoA/Rho kinase and mitogen-activated protein kinase kinase-1/extracellular signal-regulated kinase signaling pathways is required for the sphingosine-1-phosphate-induced mobilization of marrow-derived stromal cells. Stem Cells, 24(11), 2557–2565. http://dx.doi.org/10.1634/stemcells.2006-0209.

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Desrosiers, R.R., Rivard, M.E., Grundy, P.E. et Annabi, B. (2006). Decrease in LDL receptor-related protein expression and function correlates with advanced stages of Wilms tumors. Pediatric blood and Cancer, 46(1), 40–49. http://dx.doi.org/10.1002/pbc.20566.

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Ngameni, B., Touaibia, M., Patnam, R., et al. (2006). Inhibition of MMP-2 secretion in glioblastoma cells with new and known furanocoumarins and chalcones from the twigs of Dorstenia turbinate. Phytochemistry, 67(23), 2573–2579.

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Annabi, B., Bouzeghrane, M., Moumdjian, R., Moghrabi, A. et Béliveau, R. (2005). Probing the infiltrating character of brain tumors: Inhibition of RhoA/ROK-mediated CD44 cell surface shedding from glioma cells by the green tea catechin EGCg. Journal of Neurochemistry, 94(4), 906–916. http://dx.doi.org/10.1111/j.1471-4159.2005.03256.x.

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Demeule M., Annabi, B., Michaud-Levesque, J., Lamy, S. et Béliveau R. (2005). Dietary prevention of cancer : Anticancer and antiangiogenic properties of green tea polyphenols. Medicinal Chemistry Reviews, 1(1), 49–58.

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Annabi, B., Bouzeghrane, M., Currie, J.C., et al. (2005). A PSP94-derived peptide PCK3145 inhibits MMP-9 secretion and triggers CD44 cell surface shedding: Implication in tumor metastasis. Clinical and Experimental Metastasis, 22(5), 429–439. http://dx.doi.org/10.1007/s10585-005-2669-1.

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Pilorget, A., Annabi, B., Bouzeghrane, F., Marvaldi, J., Luis, J. et Beliveau, R. (2005). Inhibition of angiogenic properties of brain endothelial cells by platelet-derived sphingosine-1-phosphate. Journal of Cerebral Blood Flow and Metabolism, 25(9), 1171–1182. http://dx.doi.org/10.1038/sj.jcbfm.9600117.

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Perri, S.R., Nalbantoglu, J., Annabi, B., et al. (2005). Plasminogen kringle 5-engineered glioma cells block migration of tumor-associated macrophages and suppress tumor vascularization and progression. Cancer Research, 65(18), 8359–8365. http://dx.doi.org/10.1158/0008-5472.CAN-05-0508.

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Annabi, B., Naud, E., Lee, Y.T., Eliopoulos, N. et Galipeau, J. (2004). Vascular progenitors derived from murine bone marrow stromal cells are regulated by fibroblast growth factor and are avidly recruited by vascularizing tumors. Journal of Cellular Biochemistry, 91(6), 1146–1158. http://dx.doi.org/10.1002/jcb.10763.

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Gingras, D., Nyalendo, C., Di Tomasso, G., Annabi, B. et Béliveau, R. (2004). Activation of tissue plasminogen activator gene transcription by Neovastat, a multifunctional antiangiogenic agent. Biochemical and biophysical research communications, 320(1), 205.

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Annabi, B., Thibeault, S., Moumdjian, R. et Béliveau, R. (2004). Hyaluronan cell surface binding is induced by type I collagen and regulated by caveolae in glioma cells. Journal of Biological Chemistry, 279(21), 21888–21896. http://dx.doi.org/10.1074/jbc.M313694200.

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Annabi, B., Lee, Y.T., Turcotte, S., et al. (2003). Hypoxia promotes murine bone-marrow-derived stromal cell migration and tube formation. Stem Cells, 21(3), 337–347.

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Annabi, B., Thibeault, S., Lee, Y.T., et al. (2003). Matrix metalloproteinase regulation of sphingosine-1-phosphate-induced angiogenic properties of bone marrow stromal cells. Experimental Hematology, 31(7), 640–649. http://dx.doi.org/10.1016/S0301-472X(03)00090-0.

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Pilorget, A., Berthet, V., Luis, J., Moghrabi, A., Annabi, B. et Beliveau, R. (2003). Medulloblastoma cell invasion is inhibited by green tea (-) epigallocatechin-3-gallate. Journal of Cellular Biochemistry, 90(4), 745–755. http://dx.doi.org/10.1002/jcb.10667.

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Laplante, A., Liu, D.Y., Demeule, M., et al. (2003). Modulation of matrix gelatinases and metalloproteinase-activating process in acute kidney rejection. Transplant International, 16(4), 262–269. http://dx.doi.org/10.1007/s00147-002-0540-8.

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Annabi, B., Lee, Y.-T., Martel, C., Pilorget, A., Bahary, J.-P. et Beliveau, R. (2003). Radiation induced-tubulogenesis in endothelial cells is antagonized by the antiangiogenic properties of green tea polyphenol (-) epigallocatechin-3-gallate. Cancer Biology & Therapy, 2(6), 642–649.

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Demeule, M., Michaud-Levesque, J., Annabi, B., et al. (2002). Green Tea Catechins as Novel Antitumor and Antiangiogenic Compounds. Current Medicinal Chemistry -Anti-Cancer Agents, 2(4), 441–463. http://dx.doi.org/10.2174/1568011023353930.

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Annabi, B., Lachambre, M.P., Bousquet-Gagnon, N., Page, M., Gingras, D. et Beliveau, R. (2002). Green tea polyphenol (-)-epigallocatechin 3-gallate inhibits MMP-2 secretion and MT1-MMP-driven migration in glioblastoma cells. Biochimica et Biophysica Acta – Molecular Cell Research, 1542(1-3), 209–220.

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Annabi, B., Shedid, D., Ghosn, P., et al. (2002). Differential regulation of matrix metalloproteinase activities in abdominal aortic aneurysms. Journal of vascular surgery, 35(3), 539–546. http://dx.doi.org/10.1067/mva.2002.121124.

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Annabi, B., Lachambre, M., Bousquet-Gagnon, N., Pagé, M., Gingras, D. et Béliveau, R. (2001). Localization of membrane-type 1 matrix metalloproteinase in caveolae membrane domains. The Biochemical journal, 353(3), 547.

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Gingras, D., Bousquet-Gagnon, N., Langlois, S., Lachambre, M.-P., Annabi, B. et Béliveau, R. (2001). Activation of the extracellular signal-regulated protein kinase (ERK) cascade by membrane-type-1 matrix metalloproteinase (MT1-MMP). FEBS Letters, 507(2), 231–236. http://dx.doi.org/10.1016/S0014-5793(01)02985-4.

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Annabi, B., Pilorget, A., Bousquet-Gagnon, N., Gingras, D. et Béliveau, R. (2001). Calmodulin inhibitors trigger the proteolytic processing of membrane type-1 matrix metalloproteinase, but not its shedding in glioblastoma cells. Biochemical Journal, 359(2), 325–333. http://dx.doi.org/10.1042/0264-6021:3590325.

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Gingras, D., Page, M., Annabi, B. et Beliveau, R. (2000). Rapid activation of matrix metalloproteinase-2 by glioma cells occurs through a posttranslational MT1-MMP-dependent mechanism. Biochimica et Biophysica Acta – Molecular Cell Research, 1497(3), 341–350.

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Mechin, M.C., Annabi, B., Pegorier, J.P. et van de Werve, G. (2000). Ontogeny of the catalytic subunit and putative glucose-6-phosphate transporter proteins of the rat microsomal liver glucose-6-phosphatase system. Metabolism-clinical and experimental, 49(9), 1200–1203.

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Lin, B., Annabi, B., Hiraiwa, H., Pan, C.-J. et Chou, J.Y. (1999). Cloning and characterization of cDNAs encoding a candidate glycogen storage disease type 1b protein in rodents. Journal of Biological Chemistry, 273(48), 31656–31660. http://dx.doi.org/10.1074/jbc.273.48.31656.

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Pan, C.-J., Lei, K.-J., Annabi, B., Hemrika, W. et Chou, J.Y. (1998). Transmembrane topology of glucose-6-phosphatase. Journal of Biological Chemistry, 273(11), 6144–6148. http://dx.doi.org/10.1074/jbc.273.11.6144.

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Annabi, B., Mandel, H., Fryman, M., et al. (1998). The gene for glycogen-storage disease type lb maps to chromosome 11q23. American Journal of Human Genetics, 62(2), 400–405. http://dx.doi.org/10.1086/301727.

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Annabi, B. et Van De Werve, G. (1997). Evidence that the transit of glucose into liver microsomes is not required for functional glucose-6-phosphatase. Biochemical and Biophysical Research Communications, 236(3), 808–813. http://dx.doi.org/10.1006/bbrc.1997.6979.

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St.-Denis, J.-F., Berteloot, A., Vidal, H., Annabi, B. et Van De Werve, G. (1995). Glucose transport and glucose 6-phosphate hydrolysis in intact rat liver microsomes. Journal of Biological Chemistry, 270(36), 21092–21097. http://dx.doi.org/10.1074/jbc.270.36.21092.

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St-Denis, J.F., Annabi, B., Khoury, H. et van de Werve, G. (1995). Histone II-A stimulates glucose-6-phosphatase and reveals mannose-6-phosphatase activities without permeabilization of liver microsomes. The Biochemical journal, 310(1), 221.

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Lavoie, L., Dimitrakoudis, D., Marette, A., et al. (1993). Opposite Effects of Hyperglycemia and Insulin Deficiency on Liver Glycogen Synthase Phosphatase Activity in the Diabetic Rat. Diabetes, 42(2), 363–366. Récupéré de http://diabetes.diabetesjournals.org/content/42/2/363.abstract.

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Werve G. van de, Annabi, B., Berteloot, A., St-Denis, J.F. et Vidal, H. (1993). The hepatic glucose-6-phosphatase system : Components, kinetic properties, regulation and defects. Médecine Sciences, 9, 577–582.

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Garcia-Sainz, J.A., Alcantara-Hernandez, R., Robles-Flores, M., et al. (1992). Modulation by protein kinase-C of the hormonal responsiveness of hepatocytes from lean (Fa/fa?) and obese (fa/fa) Zucker Rats. Biochimica et Biophysica Acta, 1135(2), 221–225.

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Annabi, B., Rafei, M., Wu, J.H., Lejeune, L., Francois, M. et Galipeau, J. A GMCSF & IL15 fusokine leads to paradoxical immunosuppression in vivo via asymmetrical JAK/STAT signaling through the IL15 receptor complex Blood. Blood, 109(5), 2234–2242.

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Annabi, B. (2009). Les cellules souches cancéreuses. Le Guide des Tendances 1 (p. 98–100). Isabelle Quentin Editeur.


Demeule, M., Régina, A., Annabi, B., Bertrand, Y., Bojanowski, M.W. et Béliveau, R. (2004). Brain endothelial cells as pharmacological targets in brain tumors. Molecular Neurobiology, 30(2), 157–183.


Cours

Direction de thèses et de mémoires (Depuis 2006) et d’essais doctoraux (depuis 2014)

Mémoire de maîtrise

  • Desjarlais, M. (2014). Régulation transcriptionnelle de la MT1-MMP par la minocycline et implication dans l'autophagie des cellules d'hépatomes humains. (Mémoire de maîtrise). Université du Québec à Montréal. Récupéré d’Archipel, l’archive de publications électroniques de l’UQAM http://www.archipel.uqam.ca/6144

  • Chokor, R. (2013). Impact de l'EGCG sur la réponse à la sphingosine-1-phosphate dans un modèle de différenciation de cellules promyelomonocytaires HL-60 en macrophages. (Mémoire de maîtrise). Université du Québec à Montréal. Récupéré d’Archipel, l’archive de publications électroniques de l’UQAM http://www.archipel.uqam.ca/5814

  • Zgheib, A. (2013). L'impact de la MT1-MMP sur la régulation transcriptionelle des "colony stimulating factors" dans les cellules souches mésenchymateuses. (Mémoire de maîtrise). Université du Québec à Montréal. Récupéré d’Archipel, l’archive de publications électroniques de l’UQAM http://www.archipel.uqam.ca/5895

  • Vaillancourt-Jean, É. (2012). Ciblage pharmacologique du phénotype invasif et inflammatoire dans les cellules de médulloblastomes. (Mémoire de maîtrise). Université du Québec à Montréal. Récupéré d’Archipel, l’archive de publications électroniques de l’UQAM http://www.archipel.uqam.ca/4586

  • Proulx-Bonneau, S. (2011). Signaletic partners of MT1-MMP in hypoxic mesenchymal stem cells and survival functions in glioblastoma multiform cells. (Mémoire de maîtrise). Université du Québec à Montréal. Récupéré d’Archipel, l’archive de publications électroniques de l’UQAM http://www.archipel.uqam.ca/4235

  • Tahanian, E. (2011). Ciblage pharmacologique du phénotype angiogénique et inflammatoire des cellules endothéliales cérébrales. (Mémoire de maîtrise). Université du Québec à Montréal. Récupéré d’Archipel, l’archive de publications électroniques de l’UQAM http://www.archipel.uqam.ca/4382

  • Sina, A. (2010). Ciblage pharmacologique et rôle de MT1-MMP dans l'inflammation tumorale cérébrale. (Mémoire de maîtrise). Université du Québec à Montréal. Récupéré d’Archipel, l’archive de publications électroniques de l’UQAM http://www.archipel.uqam.ca/3594

  • Cajina Herrera, M. (2009). Mécanismes moléculaires associés à l'activité anti-tumorale et anti-angiogénique du TLN-4601 sur les glioblastomes et cellules endothéliales cérébrales humaines. (Mémoire de maîtrise). Université du Québec à Montréal. Récupéré d’Archipel, l’archive de publications électroniques de l’UQAM http://www.archipel.uqam.ca/2767

  • Laflamme, C. (2009). Caractérisation de l'axe MT1-MMP/COX-2 dans les cellules souches cancéreuses CD133(+) de glioblastome. (Mémoire de maîtrise). Université du Québec à Montréal. Récupéré d’Archipel, l’archive de publications électroniques de l’UQAM http://www.archipel.uqam.ca/2414

  • Lord-Dufour, S. (2009). Régulation du transporteur microsomial du glucose-6-phosphate par HIF1-a : impact sur la survie des cellules souches mésenchymateuses en hypoxie. (Mémoire de maîtrise). Université du Québec à Montréal. Récupéré d’Archipel, l’archive de publications électroniques de l’UQAM http://www.archipel.uqam.ca/2277

  • Fortier, S. (2008). Implication d'un axe de signalisation MT1-MMP/G6PT dans la migration et la survie des cellules souches mésenchymateuses. (Mémoire de maîtrise). Université du Québec à Montréal. Récupéré d’Archipel, l’archive de publications électroniques de l’UQAM http://www.archipel.uqam.ca/1501

  • Currie, J. (2007). Impact anti-cancéreux des catéchines du thé vert et d'un nouvel agent anti-tumoral le PCK3145 sur la régulation de la MMP-9. (Mémoire de maîtrise). Université du Québec à Montréal. Récupéré d’Archipel, l’archive de publications électroniques de l’UQAM http://www.archipel.uqam.ca/4733

  • Belkaid, A. (2007). Nouveau rôle d'un transporteur microsomal de glucose-6-phosphate dans la régulation du potentiel invasif de cellules dérivées de glioblastomes humains. (Mémoire de maîtrise). Université du Québec à Montréal. Récupéré d’Archipel, l’archive de publications électroniques de l’UQAM http://www.archipel.uqam.ca/4737

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