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Steve Bourgault

Département de chimie

Poste : Professeur

Courriel : bourgault.steve@uqam.ca

Téléphone : (514) 987-3000 poste 5161

Local : CB-3670

Domaines d'expertise

  • Fibres amyloïdes
  • Nanovaccins
  • Biophysique
  • Peptides et protéines
  • Biochimie

Langues

  • Français
  • Anglais
  • Général
  • Enseignement et supervision
  • Publications
  • Communications
  • Réalisations
  • Distinctions
  • Services à la collectivité

Cheminement académique

Stage postdoctoral, The Scripps Research Institute (2009-12)
Ph.D. Biologie, option en Chimie Médicinale, Université de Rouen (2004-09)
Ph.D. Biologie, Institut National de la Recherche Scientifique (2004-09)
M.Sc. Sciences expérimentales de la santé, Institut National de la Recherche Scientifique (2002-04)
B.Sc. Biochimie, Université du Québec à Montréal (1999-02)

Unités de recherche

  • Centre de recherche sur la conception, les mécanismes d'action et la vectorisation des médicaments (PharmaQAM)
  • Centre de recherche sur les nanomatériaux et l'énergie (NanoQAM)
  • Centre de recherches biomédicales (BIOMED)
  • Chaire de recherche du Canada en chimie des nanoassemblages biologiques

Projets de recherche en cours

  • Aucune donnée disponible pour cette section.

Partenaires (organismes, entreprises)

  • Aucune donnée disponible pour cette section.

Publications

Djerir, D., Iddir, M., Bourgault, S., Lamy, S. et Annabi, B. (2018). Biophysical evidence for differential gallated green tea catechins binding to membrane type-1 matrix metalloproteinase and its interactors. Biophysical Chemistry, 234, 34–41. http://dx.doi.org/10.1016/j.bpc.2018.01.002.


Quittot, N., Sebastiao, M., Al-Halifa, S. et Bourgault, S. (2018). Kinetic and Conformational Insights into Islet Amyloid Polypeptide Self-Assembly Using a Biarsenical Fluorogenic Probe. Bioconjugate Chemistry, 29(2), 517–527. http://dx.doi.org/10.1021/acs.bioconjchem.7b00827.


Tomas, M.B., Shiao, T.C., Nguyen, P.T., Bourgault, S. et Roy, R. (2018). Synthesis of analogs of trans-fagaramide and their cyototoxic activity. Pharmaceutical Chemistry Journal, 51(11), 995–1004. http://dx.doi.org/10.1007/s11094-018-1729-1.


Beaugrand, M., Arnold, A.A., Bourgault, S., Williamson, P.T. et Marcotte, I. (2017). Comparative study of the structure and interaction of the pore helices of the hERG and Kv1.5 potassium channels in model membranes. European Journal of Biophysics, 46(6), 549–559. http://dx.doi.org/10.1007/s00249-017-1201-2.


Quittot, N., Nguyen, P.T., Nerée, A.T., Lussier, M.P. et Bourgault, S. (2017). Identification of a Conformational Heparin-Recognition Motif on the Peptide Hormone Secretin: Key Role for Cell Surface Binding. Biochemical Journal, 474(13), 2249–2260. http://dx.doi.org/10.1042/BCJ20170035.


Quittot, N., Sebastiao, M. et Bourgault, S. (2017). Modulation of amyloid assembly by glycosaminoglycans: from mechanism to biological significance. Biochemistry and Cell Biology/Biochimie et biologie cellulaire, 95(3), 329–337. http://dx.doi.org/10.1139/bcb-2016-0236.


Nguyen, P.T., Zottig, X., Sebastiao, M. et Bourgault, S. (2017). Role of Site-Specific Asparagine Deamidation in Islet Amyloid Polypeptide Amyloidogenesis: Key Contributions of Residues 14 and 21. Biochemistry, 56(29), 3808–3817. http://dx.doi.org/10.1021/acs.biochem.7b00209.


Sebastiao, M., Quittot, N. et Bourgault, S. (2017). Thioflavin T fluorescence to analyse amyloid formation kinetics: Measurement frequency as a factor explaining irreproducibility. Analytical Biochemistry, 532, 83–86. http://dx.doi.org/10.1016/j.ab.2017.06.007.


Zottig, X., Laporte Wolwertz, M., Golizeh, M., Ohlund, L., Sleno, L. et Bourgault, S. (2016). Effects of oxidative post-translational modifications on structural stability and self-assembly of λ6 immunoglobulin light chain. Biophysical Chemistry, 219, 59–68. http://dx.doi.org/10.1016/j.bpc.2016.10.001.


Pratt, J., Iddir, M., Bourgault, S. et Annabi, B. (2016). Evidence of MTCBP-1 interaction with the cytoplasmic domain of MT1-MMP: Implications in the autophagy cell index of high-grade glioblastoma. Molecular Carcinogenesis, 55(2), 148–160. http://dx.doi.org/10.1002/mc.22264.


Nguyen, P.T., Sharma, R., Rej, R., De Carufel, C.A., Roy, R. et Bourgault, S. (2016). Low generation anionic dendrimers modulate islet amyloid polypeptide self-assembly and inhibit pancreatic b-cell toxicity. RSC Advances, 6(80), 76360–76369. http://dx.doi.org/10.1039/C6RA15373A.


Laporte Wolwertz, M., Nguyen, P.T., Quittot, N. et Bourgault, S. (2016). Probing the role of l6 immunoglobulin light chain dimerization in amyloid formation. Biochimica et Biophysica Acta (BBA) – Proteins and Proteomics, 1864(4), 409–418. http://dx.doi.org/10.1016/j.bbapap.2016.01.009.


Miloudi, K., Binet, F., Wilson, A., Oubaha, A., Menard, C., Henriques, S., Mawambo, G., Dejda, A., Nguyen, P.T., Rezende, F.A., Bourgault, S.,... Sapieha, P. (2016). Truncated Netrin-1 Contributes to Pathological Vascular Permeability in Diabetic Retinopathy. The Journal of Clinical Investigation, 126(8), 3006–3022. http://dx.doi.org/10.1172/JCI84767.


Tchoumi, N.A., Nguyen, P.T. et Bourgault, S. (2015). Cell-penetrating Ability of Peptide Hormones: Key Role of Glycosaminoglycans Clustering. International Journal of Molecular Sciences, 16(11), 27391–27400. http://dx.doi.org/10.3390/ijms161126025.


De Carufel, C.A., Quittot, N., Nguyen, P.T. et Bourgault, S. (2015). Delineating the Role of Helical Intermediates in Natively Unfolded Polypeptide Amyloid Assembly and Cytotoxicity. Angewandte Chemie International Edition, 54(48), 14383–14387. http://dx.doi.org/10.1002/anie.201507092.


Chatenet, D., Bourgault, S. et Fournier, A. (2015). Design and application of light-activated probes for cellular signaling. Methods in Molecular Biology, 1234, 17–30. http://dx.doi.org/10.1007/978-1-4939-1755-6_3.


Nguyen, P.T., Andraka, N., De Carufel, C.A. et Bourgault, S. (2015). Mechanistic Contributions of Biological Cofactors in Islet Amyloid Polypeptide Amyloidogenesis. Journal of Diabetes Research, 2015, Article ID 515307. http://dx.doi.org/10.1155/2015/515307.


Tchoumi, N.A., Nguyen, P.T., Chatenet, D., Fournier, A. et Bourgault, S. (2014). Secondary conformational conversion is involved in glycosaminoglycans-mediated cellular uptake of the cationic cell-penetrating peptide PACAP. FEBS Letters, 588(24), 4590–4596. http://dx.doi.org/10.1016/j.febslet.2014.10.029.


Hassanpour, A., De Carufel, C.A., Bourgault, S. et Forgione, P. (2014). Synthesis of 2,5-Diaryl-Substituted Thiophenes as Helical Mimetics: Towards the Modulation of Islet Amyloid Polypeptide (IAPP) Amyloid Fibril Formation and Cytotoxicity. Chemistry: A European Journal, 20(9), 2522–2528. http://dx.doi.org/10.1002/chem.201303928.


De Carufel, C.A., Nguyen, P.T., Sahnouni S. et Bourgault, S. (2013). New insights into the roles of sulfated glycosaminoglycans in islet amyloid polypeptide amyloidogenesis and cytotoxicity. Biopolymers (Peptide Science), 100(6), 645–655. http://dx.doi.org/10.1002/bip.22243.


Doan, N.D., Bourgault, S., Dejda, A., Létourneau, M., Detheux, M., Vaudry, D.,... Fournier, A. (2011). Design and in vitro characterization of PAC1/VPAC1-selective agonists with potent neuroprotective effects. Biochemical Pharmacology, 81(4), 552–561. http://dx.doi.org/10.1016/j.bcp.2010.11.015.


Solomon, J.P., Bourgault, S., Powers, E.T. et Kelly, J.W. (2011). Heparin binds 8 kDa gelsolin cross-β-sheet oligomers and accelerates amyloidogenesis by hastening fibril extension. Biochemistry, 50(13), 2486–2498. http://dx.doi.org/10.1021/bi101905n.


Dejda, A., Bourgault, S., Doan, N.D., Létourneau, M., Couvineau, A., Vaudry, H.,... Fournier, A. (2011). Identification by photoaffinity labeling of the extracellular N-terminal domain of PAC1 receptor as the major binding site for PACAP. Biochimie, 93(4), 669–677. http://dx.doi.org/10.1016/j.biochi.2010.12.010.


Bourgault, S., Choi, S., Buxbaum, J.N., Kelly, J.W., Price, J.L. et Reixach, N. (2011). Mechanisms of transthyretin cardiomyocyte toxicity inhibition by resveratrol analogs. Biochemical and Biophysical Research Communications, 410(4), 707–713. http://dx.doi.org/10.1016/j.bbrc.2011.04.133.


Dejda, A., Seaborn, T., Bourgault, S., Touzani, O., Fournier, A., Vaudry, H. et Vaudry, D. (2011). PACAP and a novel stable analog protect rat brain from ischemia: Insight into the mechanisms of action. Peptides, 32(6), 1207–1216. http://dx.doi.org/10.1016/j.peptides.2011.04.003.


Bourgault, S., Chatenet, D., Wurtz, O., Doan, N.D., Leprince, J., Vaudry, H.,... Vaudry, D. (2011). Strategies to convert PACAP from a hypophysiotropic neurohormone into a neuroprotective drug. Current Pharmaceutical Design, 17(10), 1002–1024. http://dx.doi.org/10.2174/138161211795589337.


Bourgault, S., Solomon, J.P., Reixach, N. et Kelly, J.W. (2011). Sulfated glycosaminoglycans accelerate transthyretin amyloidogenesis by quaternary structural conversion. Biochemistry, 50(6), 1001–1015. http://dx.doi.org/10.1021/bi101822y.


Bourgault, S., Vaudry, D., Ségalas-Milazzo, I., Guilhaudis, L., Couvineau, A., Laburthe, M.,... Fournier, A. (2009). Molecular and conformational determinants of pituitary adenylate cyclase-activating polypeptide (PACAP) for activation of the PAC1 receptor. Journal of Medicinal Chemistry, 52(10), 3308–3316. http://dx.doi.org/10.1021/jm900291j.


Vaudry, D., Falluel-Morel, A., Bourgault, S., Basille, M., Burel, D., Wurtz, O.,...Vaudry, H. (2009). Pituitary adenylate cyclase-activating polypeptide and its receptors: 20 years after the discovery. Pharmacological reviews, 61(3), 283–357. http://dx.doi.org/10.1124/pr.109.001370.


Bourgault, S., Vaudry, D., Dejda, A., Doan, N.D., Vaudry, H. et Fournier, A. (2009). Pituitary adenylate cyclase-activating polypeptide: focus on structure-activity relationships of a neuroprotective Peptide. Current Medicinal Chemistry, 16(33), 4462–4480. http://dx.doi.org/10.2174/092986709789712899.


Bourgault, S., Vaudry, D., Guilhaudis, L., Raoult, E., Couvineau, A., Laburthe, M.,...Fournier, A. (2008). Biological and structural analysis of truncated analogs of PACAP27. Journal of Molecular Neuroscience, 36(1-3), 260–269. http://dx.doi.org/10.1007/s12031-008-9081-7.


Doan, N.D., Bourgault, S., Létourneau, M. et Fournier, A. (2008). Effectiveness of the suzuki-miyaura cross-coupling reaction for solid-phase peptide modification. Journal of combinatorial chemistry, 10(1), 44–51. http://dx.doi.org/10.1021/cc700128b.


Dejda, A., Jolivel, V., Bourgault, S., Seaborn, T., Fournier, A., Vaudry, H. et Vaudry, D. (2008). Inhibitory effect of PACAP on caspase activity in neuronal apoptosis: a better understanding towards therapeutic applications in neurodegenerative diseases. Journal of Molecular Neuroscience, 36(1-3), 26–37. http://dx.doi.org/10.1007/s12031-008-9087-1.


Bourgault, S., Vaudry, D., Botia, B., Couvineau, A., Laburthe, M., Vaudry, H. et Fournier, A. (2008). Novel stable PACAP analogs with potent activity towards the PAC1 receptor. Peptides, 29(6), 919–932. http://dx.doi.org/10.1016/j.peptides.2008.01.022.


Bourgault, S., Létourneau, M. et Fournier, A. (2007). Development of photolabile caged analogs of endothelin-1. Peptides, 28(5), 1074–1082. http://dx.doi.org/10.1016/j.peptides.2007.02.013.


Ravni, A., Bourgault, S., Lebon, A., Chan, P., Galas, L., Fournier, A.,... Vaudry, D. (2006). The neurotrophic effects of PACAP in PC12 cells: control by multiple transduction pathways. Journal of Neurochemistry, 98(2), 321–329. http://dx.doi.org/10.1111/j.1471-4159.2006.03884.x.


Bourgault, S., Létourneau, M. et Fournier, A. (2005). Development and pharmacological characterization of "caged" urotensin II analogs. Peptides, 26(8), 1475–1480. http://dx.doi.org/10.1016/j.peptides.2005.03.019.


Brkovic, A., Hattenberger, A., Kostenis, E., Klabunde, T., Flohr, S., Kurz, M., Bourgault, S. et Fournier, A. (2003). Functional and binding characterizations of urotensin II-related peptides in human and rat urotensin-II receptor assay. The Journal of Pharmacology and Experimental Therapeutics, 306(3), 1200–1209. http://dx.doi.org/10.1124/jpet.103.052415.


Chatenet, D., Fournier, A. et Bourgault, S. (2016). PACAP-Derived carriers: mechanisms and applications. Dans D. Reglodi et A. Tamas (dir.). Pituitary Adenylate Cyclase-Activating Polypeptide – PACAP. (p. 111–132). New York : Springer.


Fournier, A., Bourgault, S. et Chatenet, D. (2016). The pharmacophoric determinants of PACAP. Dans D. Reglodi et A. Tamas (dir.). Pituitary Adenylate Cyclase-Activating Polypeptide – PACAP. (p. 133–148). New York : Springer.


Zottig, X., Archambault, M.J., Rouiller, I. et Bourgault, S. (2017). Amyloid mono-assemblies: bioorthogonal conjugation via enzymatic-mediated ligation. Dans 17th PROTEO Annual Symposium, Québec, mai 2017.


Sebastiao, M., Quittot, N. et Bourgault, S. (2017). Contribution of measurement frequency in the kinetics of amyloid fibril formation. Dans 13th Annual Symposium of BioMed Research Center, Montréal, avril 2017.


Quittot, N., Nguyen, P.T., Tchoumi Nerée, A., Lussier, M. et Bourgault, S. (2017). Contributions of glycosaminoglycans to membrane adsorption and conformational conversion of peptide hormones. Dans Biophysical Society 61st Annual Meeting, Nouvelle-Orléans, février 2017.


Zottig, X., Archambault, M.J., Rouiller, I. et Bourgault, S. (2017). Covalent immobilization of proteins onto self-assembled nanostructures via an enzymatic-mediated ligation. Dans 3rd Annual Meeting of the Biophysical Society of Canada, Montréal, mai 2017.


Nguyen P.T., S., R., Rej, R., De Carufel, C.A., Roy, R. et Bourgault, S. (2017). Design and Validation of Multi-Charged Dendrimers to Modulate Amyloid Assembly. Dans 3rd Annual Meeting of the Biophysical Society of Canada, Montréal, mai 2017.


Bourgault, S., Babych, M., Zottig, X., Bertheau-Mailhot, G., Dion, J. et Archambault, D. (2017). Design and validation of self-assembled peptide nanostructuresas a novel vaccination Platform. Dans Modern vaccines adjuvants and delivery systems conference 2017, Porto, septembre 2017.


Babych, M., Zottig, X., Bertheau-Mailhot, G., Dion, J., Archambault, D. et Bourgault, S. (2017). Design of amyloid-based nanostructures as a novel vaccination platform. Dans 3rd Annual Meeting of the Biophysical Society of Canada, Montréal, mai 2017.


Quittot, N., Hicheur, M., Sebastiao, M. et Bourgault, S. (2017). Development of a new fluorescence based assay to study the formation of amyloid fibril. Dans 13th Annual Symposium of BioMed Research Center, Montréal, avril 2017.


Zottig, X., Archambault, M.A., Rouiller, I. et Bourgault, S. (2017). Enzymatic-mediated functionalization of amyloid fibrils. Dans 13th Annual Symposium of BioMed Research Center, Montréal, avril 2017.


Quittot, N., Nguyen, P.T., Tchoumi Nerée, A., Lussier, M. et Bourgault, S. (2017). Identification of a conformationalheparin-recognition motif on the peptide hormone secretin: key role for cellsurface binding. Dans Protein Society 31st Annual Symposium, Montréal, juillet 2017.


Djerir, B., Ghilarducci, K., Lussier, M.P. et Bourgault, S. (2017). Implementation of Screening Assay for Hypoxia Induced Factor Inhibitors: Therapeutic Target for Tumor Progression. Dans 3rd Annual Meeting of the Biophysical Society of Canada, Montréal, mai 2017.


Nguyen, P.T., Zottig, X. et Bourgault, S. (2017). Insights into the contributions of residues Asn-14 and Asn-21 in islet amyloid polypeptide self-assembly. Dans 17th PROTEO Annual Symposium, Montréal, mai 2017.


Nguyen, P.T., Sharma, R., Rej, R., De Carufel, C.A., Roy, R. et Bourgault, S. (2017). Manipulating amyloid assembly with densely-charged low generation dendrimers. Dans 13th Annual Symposium of BioMed Research Center, Montréal, avril 2017.


Zottig, X., Laporte Wolwertz, M., Golizeh, M., Ohlund, L., Sleno, L. et Bourgault, S. (2017). Mechanism of immunoglobulin light chain self-assembly: contributions of tyrosine and histidine chemical modifications. Dans Protein Society 31st Annual Symposium, Montréal, juillet 2017.


Sebastiao, M., Quittot, N. et Bourgault, S. (2017). Modulation of amyloidogenic kinetics by the interval of fluorescence measurement: a key factor explaining irreproducibility. Dans 17th PROTEO Annual Symposium, Québec, mai 2017.


Quittot, N., Hicheur, M., Sebastiao, M. et Bourgault, S. (2017). Monitoring the self-assembly of amyloidogenic polypeptide by a novel fluorescence based assay. Dans 17th PROTEO Annual Symposium, Québec, mai 2017.


Quittot, N., Hicheur, M., Sebastiao, M. et Bourgault, S. (2017). New insights into the mechanism of islet amyloid polypeptide self-assembly by mean of a split tetra-Cys motif approach. Dans 3rd Annual Meeting of the Biophysical Society of Canada, Montréal, mai 2017.


Dion, J., Bertheau-Mailhot, G., Marchand, C., Bourgault, S. et Archambault, D. (2017). P97C recombinant protein modulates the innate immune system through TLR5 activation. Dans 13th Annual Symposium of BioMed Research Center, Montréal, avril 2017.


Archambault, D., Dion, J., Bertheau-Mailhot, G., Marchand, C. et Bourgault, S. (2017). P97c recombinant protein modulates the innateimmune system through Toll-like receptor 5 (TLR5) activation and cytokineproduction. Dans Modern vaccines adjuvants and delivery systems conference 2017, Porto, septembre 2017.


Sebastiao, M., Marcotte, I. et Bourgault, S. (2017). Probing the mechanism of glycosaminoglycan-mediated amyloid assembly with a non-amyloidogenic peptide model. Dans Biophysical Society 61st Annual Meeting, Nouvelle-Orléans, février 2017.


Nguyen, P.T., Zottig, X. et Bourgault, S. (2017). Roles of site-specific deamidation in islet amyloid polypeptide self-assembly and cytotoxicity. Dans Biophysical Society 61st Annual Meeting, Nouvelle-Orléans, février 2017.


Babych, M., Zottig, X., Bertheau-Mailhot, G., Dion, J., Archambault, D. et Bourgault, S. (2017). Self-assembled amyloid nanostructures for vaccine development. Dans 13th Annual Symposium of BioMed Research Center, Montréal, avril 2017.


Babych, M., Zottig, X., Bertheau-Mailhot, G., Dion, J., Archambault, D. et Bourgault, S. (2017). Self-assembled cross-β-sheet peptide nanofibers as a novel vaccination platform. Dans 17th PROTEO Annual Symposium, Québec, mai 2017.


Ghilarducci, K., Djerir, B., Bourgault, S. et Lussier, M.P. (2017). Study of the functional interaction between Ubiquitin ligase E3 RNF 167 and a library of conjugating ubiquitin E2. Dans 17th PROTEO Annual Symposium, Québec, mai 2017.


Sebastiao, M., Marcotte, I. et Bourgault, S. (2017). Sulfated glycosaminoglycans induce an amyloid aggregation of a non-pathogenic neuropeptide. Dans Protein Society 31st Annual Symposium, Montréal, juillet 2017.


Sebastiao, M., Quittot, N. et Bourgault, S. (2017). Thioflavin T fluorescence to detect amyloid assembly: effect of the frequency of measurement in microplate assays. Dans 3rd Annual Meeting of the Biophysical Society of Canada, Montréal, mai 2017.


Zottig, X., Laporte Wolwertz, M., Golizeh, M., Ohlund, L., Sleno, L. et Bourgault, S. (2016). Contributions of tyrosine nitration and histidine carbonylation in the amyloid assembly of immunoglobulin light chains. Dans 2nd Protein Engineering Canada Conference, Ottawa, juin 2016.


Nguyen, P.T., Sharma, R., Rej, R., De Carufel, C.A. et Bourgault, S. (2016). Design and validation of multi-charged dendrimers to manipulate amyloid assembly. Dans Annual GRASP Symposium, Montréal, novembre 2016.


Quittot, N., Hicheur, M. et Bourgault, S. (2016). Development of a novel fluorescence-based assay to monitor amyloid assembly. Dans Annual GRASP Symposium, Montréal, novembre 2016.


Djerir, B., Ghilarducci, K., Bourgault, S. et Lussier, M.P. (2016). Development of biochemical and biophysical assays for validating functional interacting partners of the ubiquitin ligase RNF167. Dans Annual GRASP Symposium, Montréal, novembre 2016.


Sebastiao, M., Marcotte, I. et Bourgault S. (2016). Glycosaminoglycans promote the amyloid assembly of a non-amyloidogenic peptide hormone. Dans Annual GRASP Symposium, Montréal, novembre 2016.


Zottig, X., Laporte Wolwertz, M., Golizeh, M., Ohlund, L., Sleno, L. et Bourgault, S. (2016). Mechanism of immunoglobulin light chain self-assembly: contributions of tyrosine and histidine chemical modifications. Dans 2nd Annual Meeting of the Biophysical Society of Canada, Winnipeg, juin 2016.


Nguyen, P.T., Zottig, X. et Bourgault, S. (2016). Site-specific asparagine deamidation accelerates islet amyloid polypeptide self-assembly. Dans 2nd Annual Meeting of the Biophysical Society of Canada, Winnipeg, juin 2016.


Zottig, X., Archambault, M.J., Rouiller, I. et Bourgault, S. (2016). The amyloid supramolecular structure as a functional nanomaterial. Dans Annual GRASP Symposium, Montréal, novembre 2016.


De Carufel, C.A., Quittot, N. Nguyen, P.T. et Bourgault, S. (2016). Understanding amyloid assembly of natively unfolded polypeptide by means of conformationally restricted peptides. Dans Biophysical Society 60th Annual Meeting, Los Angeles, février 2016.


Nguyen, P.T., Babych, M. et Bourgault, S. (2015). Asparagine deamidation modulates Islet Amyloid Polypeptide amyloid formation. Dans Annual GRASP Symposium, Montréal, novembre 2015.


Tchoumi Nerée, A., Laporte Wolwertz, M., Nguyen, P.T. et Bourgault, S. (2015). Cell surface glycosaminoglycans mediate plasma membrane adsorption of cationic peptide hormones: cellular and biophysical characterization. Dans 15th Annual Symposium of PROTEO, Québec, mai 2015.


De Carufel, C.A., Nguyen, P.T., Arnold, A., Marcotte, I. et Bourgault, S. (2015). Destabilizing the Transient α-helical Conformation of Islet Amyloid Polypeptide hastens peptide self-assembly and potentiates cytotoxicity. Dans 29th Annual Symposium of The Protein Society, Barcelone, juillet 2015.


Djerir, B., Quittot, N., Lussier, M.P. et Bourgault, S. (2015). Development of biophysical assays to study the heterodimerization of hypoxia inducible factors. Dans Annual GRASP Symposium, Montréal, novembre 2015.


Laporte Wolwertz, M., Nguyen, P.T. et Bourgault, S. (2015). Dissecting the pathway of immunoglobulin light chain amyloidogenesis: existence of an off-pathway native-like oligomer. Dans Annual Meeting of the Biophysical Society of Canada, Waterloo, juin 2015.


Nguyen, P.T., Babych, M. et Bourgault, S. (2015). Effects of non-enzymatic post-translational modifications on Islet Amyloid Polypeptide fibrillogenesis. Dans 15th Annual Symposium of PROTEO, Québec, mai 2015.


De Carufel, C.A., Quittot, N., Nguyen, P.T. et Bourgault, S. (2015). Elucidating the roles of helical conformational conversion in Islet Amyloid Polypeptide amyloid formation. Dans 15th Annual Symposium of PROTEO, Québec, mai 2015.


Tchoumi Nerée, A., Nguyen, P.T. et Bourgault, S. (2015). Importance of Secondary Conformational Conversion in Glycosaminoglycans-Mediated Cellular Uptake. Dans 24th American Peptide Symposium, Orlando, juin 2015.


De Carufel, C.A., Nguyen P.T. et Bourgault, S. (2015). Investigating the Role of Helical Intermediates in Amylin Amyloid Formation. Dans 24th American Peptide Symposium, Orlando, juin 2015.


Quittot, N., Nguyen, P.T. et Bourgault, S. (2015). Mechanisms of islet amyloid polypeptide self-assembly: role of helical folding in amyloidogenesis and b-cells toxicity. Dans Annual GRASP Symposium, Montréal, novembre 2015.


Babych, M., Nguyen, P.T. et Bourgault, S. (2015). Probing the effect of protein carbonylation on amyloid formation with site-specifically modified peptide derivatives. Dans Québec and Ontario Mini-Symposium in Synthetic and Bioorganic Chemistry, Montréal, novembre 2015.


Laporte Wolwertz, M., Nguyen P.T. et Bourgault, S. (2015). Probing the pathway of lambda-6 immunoglobulin light chain amyloid formation. Dans 15th Annual Symposium of PROTEO, Québec, mai 2015.


De Carufel, C.A., Nguyen, P.T., Arnold, A., Marcotte, I. et Bourgault, S. (2015). Understanding Islet Amyloid Polypeptide Amyloid Formation and Cytotoxicity by Conformationally Restricted Derivatives. Dans Annual Meeting of the Biophysical Society of Canada, Waterloo, juin 2015.


Laporte Wolwertz, M., Nguyen, P.T. et Bourgault, S. (2014). Comparative study of amyloid fibril formation of two l6 immunoglobulin light chain proteins. Dans 97th Canadian Chemistry Conference and Exhibition, Vancouver, juin 2014.


Laporte Wolwertz, M., Nguyen, P.T. et Bourgault, S. (2014). Dissecting the pathway of immunoglobulin light chain amyloidogenesis: existence of an off-pathway native-like oligomer. Dans Annual GRASP Symposium, Montréal, novembre 2014.


De Carufel, C.A., Arnold, A., Marcotte I. et Bourgault, S. (2014). Impact of Islet amyloid polypeptide (IAPP) amyloid formation on the integrity of model membranes studied by NMR. Dans XXVIIth MOOT NMR Symposium, Montréal, octobre 2014.


Tchoumi Nerée, A., Nguyen, P.T. et Bourgault, S. (2014). Importance des transitions conformationnelles pour l’internalisation d’un peptide de pénétration cellulaire cationique, le Pituitary Adenylate Cyclase-Activating Polypeptide. Dans Journée Phare 2014, Orford, novembre 2014.


Tchoumi Nerée, A., Nguyen, P.T., Fournier, A., Chatenet, D. et Bourgault, S. (2014). Key role of cell surface glycosaminoglycans clustering in the biological uptake of the peptidic hormone PACAP. Dans 14th Annual Symposium of PROTEO, Québec, mai 2014.


Nguyen, P.T., Tremblay, C., De Carufel, C.A. et Bourgault, S. (2014). Oxidative stress metabolites accelerate islet amyloid polypeptide (IAPP) amorphous aggregation. Dans 14th Annual Symposium of PROTEO, Québec, mai 2014.


De Carufel, C.A., Nguyen, P.T., Arnold, A., Marcotte, I. et Bourgault, S. (2014). Probing the helical intermediates in IAPP amyloid formation. Dans Annual GRASP Symposium, Montréal, novembre 2014.


Laporte Wolwertz, M., Nguyen, P.T. et Bourgault, S. (2014). Self-assembly of immunoglobulin light chain into native-like oligomers can be off-pathway to amyloid fibrils formation. Dans 14th Annual Symposium of PROTEO, Québec, mai 2014.


Tchoumi Nerée, A., Laporte Wolwertz, M., Nguyen, P.T. et Bourgault, S. (2014). The membrane catalysis hypothesis for peptide-receptor binding revisited. Dans Annual GRASP Symposium, Montréal, novembre 2014.


Laporte Wolwertz, M., Nguyen, P.T. et Bourgault, S. (2014). Étude de l’auto-assemblage de chaînes légères d’anticorps en fibres amyloïdes, implication de la formation d’oligomères de conformation native. Dans Journée Phare 2014, Orford, novembre 2014.


De Carufel, C.A., Nguyen, P.T. et Bourgault, S. (2014). Étude des intermédiaires hélicoïdaux dans la formation de fibres amyloïdes. Dans Journée Phare 2014, Orford, novembre 2014.


Carufel, C.A., Nguyen, P.T. et Bourgault, S. (2013). Biochemical mechanisms of peptide amyloid fibrils formation; a focus on the islet amyloid polypeptide. Dans 96th Canadian Chemistry Conference & Exhibition, Québec, mai 2013.


Nguyen, P.T., Laporte Wolwertz, M., Kemoe, E.F. et Bourgault, S. (2013). Caractérisation biologique et biophysique des interactions entre la sécrétine et les glycosaminoglycanes sulfatés. Dans Colloque nouvelles avancées en science des peptides, 81e congrès de l'ACFAS, Québec, mai 2013.


Sahnouni, S., De Carufel, C.A. et Bourgault, S. (2013). Effets des produits de la peroxydation lipidique sur l’amyloïdogenèse et la cytotoxicité de l’islet amyloid polypeptide. Dans Colloque nouvelles avancées en science des peptides, 81e congress de l'ACFAS, Québec, mai 2013.


De Carufel, C.A., Nguyen, P.T. et Bourgault, S. (2013). Glycosaminoglycans accelerate islet amyloid polypeptide (IAPP) fibrils formation and protect pancreatic cells against IAPP-induced toxicity. Dans Symposium annuel de PROTEO, Québec, mai 2013.


De Carufel, C.A., Sharma, R., Roy, R. et Bourgault, S. (2013). Modulation de l’agrégation et de la toxicité de l’islet amyloid polypeptide par des composés polyalcool et polyacide. Dans Colloque nouvelles avancées en science des peptides, 81e congrès de l'ACFAS, Québec, mai 2013.


Lamine, A., Doan, N.D., Létourneau, M., Vaudry, D., Vaudry, H., Bourgault, S.,... Fournier, A. (2013). Potent reduced-size analogs of PACAP: The 11th International Symposium on VIP, PACAP and Related Peptides 27–31 August 2013 PÉCS, Hungary. Dans Journal of Molecular Neuroscience, 51(Suppl. 1), S204. http://dx.doi.org/10.1007/s12031-013-0105-6.


Doan, N.D., Bourgault, S., Letourneau, M., Vaudry, D., Detheux, M., Vaudry, H.,... Fournier, A. (2012). How specific are the antagonists of PACAP receptors: 10th International Symposium on VIP-PACAP and Related Peptides, December 13–16, 2011 Eilat, Israel. Dans Journal of Molecular Neuroscience, 48(Suppl. 1), S161. http://dx.doi.org/10.1007/s12031-011-9684-2.


Nguyen, P.T., Laporte Wolwertz, M., De Carufel, C.A. et Bourgault, S. (2012). Interactions between sulfated glycosaminoglycans and the peptide hormone secretin. Dans The Sixth Peptide Engineering Meeting (PEM6), Atlanta, octobre 2012.


Dejda, A., Seaborn, T., Bourgault, S., Touzani, O., Fournier, A., Vaudry, H. et Vaudry, D. (2012). PACAP and a novel stable analogue protect rat brain from ischemia through same mechanisms: 10th International Symposium on VIP-PACAP and Related Peptides, December 13–16, 2011 Eilat, Israel. Dans Journal of Molecular Neuroscience, 48(Suppl. 1), S158-S159. http://dx.doi.org/10.1007/s12031-011-9684-2.


De Carufel, C.A., Laporte Wolwertz, M. et Bourgault, S. (2012). Roles of cell-surface glycosaminoglycans in islet amyloid polypeptide-induced cytotoxicity. Dans The Sixth Peptide Engineering Meeting (PEM6), Atlanta, octobre 2012.


De Carufel, C.A., Sahnouni, S. et Bourgault, S. (2012). Rôles des glycosaminoglycanes dans l’amyloïdogenèse de l’islet amyloid polypeptide. Dans 4ieme colloque annuel Pharmaqam et 2ieme journée scientifique RQRM, Montréal, septembre 2012.


Vaudry, D., Bourgaut, S., Doan, N.D., Basille, M., Botia, B., Dejda, A.,... Fournier, A. (2010). Characterization of some neurotrophic activities of PACAP and development of new analogs for in vivo treatments. Dans 18th International Symposium on Regulatory Peptides, Belfast, septembre 2010.


Vaudry, D., Bourgaut, S., Doan, N.D., Basille, M., Botia, B., Dejda, A.,... Fournier, A. (2010). Characterization of the neurotrophic effects of PACAP and development of new analogs for therapeutic applications. Dans The 7th Joint Meeting of the European Neuropeptide Club and the American Summer Neuropeptide, Pecs, juin 2010.


Doan, N.D., Dejda, A., Bourgault, S., Vaudry, D., Letourneau, M., Detheux, M.,... Fournier, A. (2010). Design of PAC1/VPAC1 selective analogs as multifunctional drug candidates for the treatment of Parkinson's disease. Dans Thirty-First European Peptide Symposium, Copenhague, septembre 2010.


Doan, N.D., Bourgault, S., Vaudry, D., Chatenet, D., Vaudry, H. et Fournier, A. (2009). Key pharmacophore elements of the N-terminal domain of PACAP. Dans 9th International Symposium on VIP, PACAP and Related Peptides, Kagoshima, octobre 2010.


Bourgault, S., Vaudry, D., Couvineau, A., Laburthe, M., Vaudry, H. et Fournier, A. (2009). Probing the active conformation of the neuropeptide PACAP. Dans 5th International Symposium on Peptide Receptors, Québec, juin 2009.


Bourgault, S., Vaudry, D., Couvineau, A., Doan, N.D., Laburthe, M., Vaudry, H. et Fournier, A. (2008). Structure-activity relationship studies of pituitary adenylate cyclase-activating polypeptide: Ala-scan of the N-terminal domain. Dans 30th European Peptide Symposium, septembre 2008.


Cours

Direction (Depuis 1990) et d’essais doctoraux (depuis 2014)

  • Djerir, Billel. (2017). Développement d'essais de criblage d'inhibiteurs de l'hétérodimérisation des facteurs inductibles par l'hypoxie. (Mémoire de maîtrise). Université du Québec à Montréal. Récupéré d’Archipel, l’archive de publications électroniques de l’UQAM. http://www.archipel.uqam.ca/10763.

  • Laporte Wolwertz, Mathieu. (2016). Mécanismes biochimiques de l'amyloïdose à chaînes légères. (Mémoire de maîtrise). Université du Québec à Montréal. Récupéré d’Archipel, l’archive de publications électroniques de l’UQAM. http://www.archipel.uqam.ca/8633.

  • De Carufel, Carole Anne. (2016). Étude des mécanismes moléculaires de l'amyloïdogenèse et de la cytotoxicité de l'islet amyloid polypeptide (IAPP). (Mémoire de maîtrise). Université du Québec à Montréal. Récupéré d’Archipel, l’archive de publications électroniques de l’UQAM. http://www.archipel.uqam.ca/8658.

  • Tchoumi Nerée, Armelle. (2016). Caractérisation biophysique et rôles biologiques des interactions hormone peptidique-glycosaminoglycane. (Mémoire de maîtrise). Université du Québec à Montréal. Récupéré d’Archipel, l’archive de publications électroniques de l’UQAM. http://www.archipel.uqam.ca/8725.

Autres directions et supervisions

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Communications

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