Diana Alison Averill

Diana Alison Averill

Professeure
Photo de Diana Alison Averill
Informations générales

Unités de recherche

  • Centre de recherche en toxicologie de l'environnement (TOXEN)
Enseignement

Directions de thèses et mémoires

Thèses de doctorat
Mémoires

Publications

Articles scientifiques
  • Redza-Dutordoir, M. et Averill-Bates, D.A. (2016). Activation of apoptosis signalling pathways by reactive oxygen species. Biochimica et Biophysica Acta (BBA) – Molecular Cell Research, 1863(12), 2977–2992. http://dx.doi.org/10.1016/j.bbamcr.2016.09.012.
  • Redza-Dutordoir, M., Kassis, S., Ve, H., Grondin, M. et Averill-Bates, D.A. (2016). Inhibition of autophagy sensitises cells to hydrogen peroxide-induced apoptosis: Protective effect of mild thermotolerance acquired at 40°C. Biochimica et Biophysica Acta (BBA) – Molecular Cell Research, 1863(12), 3050–3064. http://dx.doi.org/10.1016/j.bbamcr.2016.09.015.
  • Chow-Shi-Yée, M., Briard, J.G., Grondin, M., Averill-Bates, D.A., Ben, R.N. et Ouellet, F. (2016). Inhibition of ice recrystallization and cryoprotective activity of wheat proteins in liver and pancreatic cells. Protein Science, 25(5), 974–986. http://dx.doi.org/10.1002/pro.2903.
  • Chow-Shi-Yée, M., Grondin, M., Averill-Bates, D.A. et Ouellet, F. (2016). Plant protein 2-Cys peroxiredoxin TaBAS1 alleviates oxidative and nitrosative stresses incurred during cryopreservation of mammalian cells. Biotechnology and Bioengineering, 113(7), 1511–1521. http://dx.doi.org/10.1002/bit.25921.
  • Glory, A. et Averill-Bates, D.A. (2016). The antioxidant transcription factor Nrf2 contributes to the protective effect of mild thermotolerance (40°C) against heat shock-induced apoptosis. Free Radical Biology and Medicine, 99, 485–497. http://dx.doi.org/10.1016/j.freeradbiomed.2016.08.032.
  • Séïde, M., Marion, M., Mateescu, M.A. et Averill-Bates, D.A. (2016). The fungicide thiabendazole causes apoptosis in rat hepatocytes. Toxicology in Vitro, 32, 232–239. http://dx.doi.org/10.1016/j.tiv.2015.12.018.
  • Bettaieb, A. et Averill-Bates, D.A. (2015). Thermotolerance induced at a mild temperature of 40°C alleviates heat shock-induced ER stress and apoptosis in HeLa cells. Biochimica et Biophysica Acta (BBA) – Molecular Cell Research, 1853(1), 52–62. http://dx.doi.org/10.1016/j.bbamcr.2014.09.016.
  • Grondin, M., Chow-Shi-Yée, M., Ouellet, F. et Averill-Bates, D.A. (2015). Wheat enolase demonstrates potential as a non-toxic cryopreservation agent for liver and pancreatic cells. Biotechnology Journal, 10(5), 801–810. http://dx.doi.org/10.1002/biot.201400562.
  • Tanel, A., Pallepati, P., Bettaieb, A., Morin, P. et Averill-Bates, D.A. (2014). Acrolein activates cell survival and apoptotic death responses involving the endoplasmic reticulum in A549 lung cells. Biochimica et Biophysica Acta (BBA) – Molecular Cell Research, 1843(5), 827–835. http://dx.doi.org/10.1016/j.bbamcr.2013.12.012.
  • Glory, A., Bettaieb, A. et Averill-Bates, D.A. (2014). Mild thermotolerance induced at 40 °C protects cells against hyperthermia-induced pro-apoptotic changes in Bcl-2 family proteins. International Journal of Hyperthermia, 30(7), 502–512. http://dx.doi.org/10.3109/02656736.2014.968641.
  • Grondin, M., Robinson, I., Do Carmo, S., Ali-Benali, M.A., Ouellet, F., Mounier, C., Sarhan, F. et Averill-Bates, D.A. (2013). Cryopreservation of insulin-secreting INS832/13 cells using a wheat protein formulation. Cryobiology, 66(2), 136–143. http://dx.doi.org/10.1016/j.cryobiol.2012.12.008.
  • Pallepati, P. et Averill-Bates, D.A. (2011). Activation of ER stress and apoptosis by hydrogen peroxide in HeLa cells: Protective role of mild heat preconditioning at 40°C. Biochimica et Biophysica Acta (BBA) – Molecular Cell Research, 1813(12), 1987–1999. http://dx.doi.org/10.1016/j.bbamcr.2011.07.021.
  • Pallepati, P. et Averill-Bates, D.A. (2011). Mild thermotolerance induced at 40 °c protects HeLa cells against activation of death receptor-mediated apoptosis by hydrogen peroxide. Free Radical Biology and Medicine, 50(6), 667–679. http://dx.doi.org/10.1016/j.freeradbiomed.2010.11.022.
  • Roy, J., Pallepati, P., Bettaieb, A. et Averill-Bates, D.A. (2010). Acrolein induces apoptosis through the death receptor pathway in A549 lung cells: Role of p53. Canadian Journal of Physiology and Pharmacology/Revue canadienne de physiologie et pharmacologie, 88(3), 353–368. http://dx.doi.org/10.1139/Y09-134.
  • Pallepati, P. et Averill-Bates, D. (2010). Mild thermotolerance induced at 40 °C increases antioxidants and protects HeLa cells against mitochondrial apoptosis induced by hydrogen peroxide: Role of p53. Archives of Biochemistry and Biophysics, 495(2), 97–111. http://dx.doi.org/10.1016/j.abb.2009.12.014.
  • Roy, J., Pallepati, P., Bettaieb, A., Tanel, A. et Averill-Bates, D.A. (2009). Acrolein induces a cellular stress response and triggers mitochondrial apoptosis in A549 cells. Chemico-Biological Interactions, 181(2), 154–167. http://dx.doi.org/10.1016/j.cbi.2009.07.001.
  • Grondin, M., Hamel, F., Averill-Bates, D.A. et Sarhan, F. (2009). Wheat proteins enhance stability and function of adhesion molecules in cryopreserved hepatocytes. Cell Transplantation, 18(1), 79–88. http://dx.doi.org/10.3727/096368909788237104.
  • Grondin, M., Hamel, F., Averill-Bates, D.A. et Sarhan, F. (2009). Wheat proteins improve cryopreservation of rat hepatocytes. Biotechnology and Bioengineering, 103(3), 582–591. http://dx.doi.org/10.1002/bit.22270.
  • Haidara, K., Marion, M., Gascon-Barré, M., Denizeau, F. et Averill-Bates, D.A. (2008). Implication of caspases and subcellular compartments in tert-butylhydroperoxide induced apoptosis. Toxicology and Applied Pharmacology, 229(1), 65–76. http://dx.doi.org/10.1016/j.taap.2008.01.010.
  • Averill-Bates, D.A., Ke, Q., Tanel, A., Roy, J., Fortier, G. et Agostinelli, E. (2008). Mechanism of cell death induced by spermine and amine oxidase in mouse melanoma cells. International Journal of Oncology, 32(1), 79–88. Récupéré de https://pdfs.semanticscholar.org/e01f/d456961e34d2e54b6a27f070679151bd67f7.pdf.
  • Grondin, M., Hamel, F., Sarhan, F. et Averill-Bates, D.A. (2008). Metabolic activity of cytochrome P450 isoforms in hepatocytes cryopreserved with wheat protein extract. Drug Metabolism and Disposition, 36(10), 2121–2129. http://dx.doi.org/10.1124/dmd.108.021162.
  • Wrzal, P.K., Bettaieb, A. et Averill-Bates, D.A. (2008). Molecular mechanisms of apoptosis activation by heat shock in multidrug-resistant Chinese hamster cells. Radiation Research, 170(4), 498–511. http://dx.doi.org/10.1667/RR1214.1.
  • Bettaieb, A. et Averill-Bates, D.A. (2008). Thermotolerance induced at a fever temperature of 40°C protects cells against hyperthermia-induced apoptosis mediated by death receptor signalling. Biochemistry and cell biology/Biochimie et biologie cellulaire, 86(6), 521–538. http://dx.doi.org/10.1139/O08-136.
  • Tanel, A. et Averill-Bates, D.A. (2007). Activation of the death receptor pathway of apoptosis by the aldehyde acrolein. Free Radical Biology and Medicine, 42(6), 798–810. http://dx.doi.org/10.1016/j.freeradbiomed.2006.12.009.
  • Tanel, A. et Averill-Bates, D.A. (2007). Inhibition of acrolein-induced apoptosis by the antioxidant N-acetylcysteine. Journal of Pharmacology and Experimental Therapeutics, 321(1), 73–83. http://dx.doi.org/10.1124/jpet.106.114678.
  • Tanel, A. et Averill-Bates, D.A. (2007). P38 and ERK mitogen-activated protein kinases mediate acrolein-induced apoptosis in Chinese hamster ovary cells. Cellular Signalling, 19(5), 968–977. http://dx.doi.org/10.1016/j.cellsig.2006.10.014.
  • Okoumassoun, L., Averill-Bates, D., Denizeau, F. et Henderson, J.E. (2007). Parathyroid hormone related protein (PTHrP) inhibits TNFα-induced apoptosis by blocking the extrinsic and intrinsic pathways. Journal of Cellular Physiology, 210(2), 507–516. http://dx.doi.org/10.1002/jcp.20892.
  • Okoumassoun, L.E., Russo, C., Denizeau, F., Averill-Bates, D. et Henderson, J.E. (2007). Parathyroid Hormone-related Protein (PTHrP) inhibits mitochondrial- dependent apoptosis through CK2. Journal of Cellular Physiology, 212(3), 591–599. http://dx.doi.org/10.1002/jcp.21055.
  • Grondin, M., Marion, M., Denizeau, F. et Averill-Bates, D.A. (2007). Tributyltin induces apoptotic signaling in hepatocytes through pathways involving the endoplasmic reticulum and mitochondria. Toxicology and Applied Pharmacology, 222(1), 57–68. http://dx.doi.org/10.1016/j.taap.2007.03.028.
  • Hamel, F., Grondin, M., Denizeau, F., Averill-Bates, D.A. et Sarhan, F. (2006). Wheat extracts as an efficient cryoprotective agent for primary cultures of rat hepatocytes. Biotechnology and Bioengineering, 95(4), 661–670. http://dx.doi.org/10.1002/bit.20953.
  • Averill-Bates, D.A., Chérif, A., Agostinelli, E., Tanel, A. et Fortier, G. (2005). Anti-tumoral effect of native and immobilized bovine serum amine oxidase in a mouse melanoma model. Biochemical Pharmacology, 69(12), 1693–1704. http://dx.doi.org/10.1016/j.bcp.2005.02.025.
  • Tanel, A. et Averill-Bates, D.A. (2005). The aldehyde acrolein induces apoptosis via activation of the mitochondrial pathway. Biochimica et Biophysica Acta (BBA) – Molecular Cell Research, 1743(3), 255–267. http://dx.doi.org/10.1016/j.bbamcr.2004.11.007.
  • Bettaieb, A. et Averill-Bates, D.A. (2005). Thermotolerance induced at a mild temperature of 40°C protects cells against heat shock-induced apoptosis. Journal of Cellular Physiology, 205(1), 47–57. http://dx.doi.org/10.1002/jcp.20386.
  • Jurkiewicz, M., Averill-Bates, D.A., Marion, M. et Denizeau, F. (2004). Involvement of mitochondrial and death receptor pathways in tributyltin-induced apoptosis in rat hepatocytes. Biochimica et Biophysica Acta (BBA) – Molecular Cell Research, 1693(1), 15–27. http://dx.doi.org/10.1016/j.bbamcr.2004.04.001.
  • Souslova, T. et Averill-Bates, D.A. (2004). Multidrug-resistant hela cells overexpressing MRP1 exhibit sensitivity to cell killing by hyperthermia: Interactions with etoposide. International Journal of Radiation Oncology Biology Physics, 60(5), 1538–1551. http://dx.doi.org/10.1016/j.ijrobp.2004.07.686.
  • Saavedra, Y.G.L., Mateescu, M.A., Averill-Bates, D.A. et Denizeau, F. (2003). Polyvinylalcohol three-dimensional matrices for improved long-term dynamic culture of hepatocytes. Journal of Biomedical Materials Research – Part A, 66A(3), 562–570. http://dx.doi.org/10.1002/jbm.a.10583.
  • Okoumassoun, L.-E., Averill-Bates, D., Marion, M. et Denizeau, F. (2003). Possible mechanisms underlying the mitogenic action of heptachlor in rat hepatocytes. Toxicology and Applied Pharmacology, 193(3), 356–369. http://dx.doi.org/10.1016/j.taap.2003.07.010.
  • Okoumassoun, L.-E., Averill-Bates, D., Gagné, F., Marion, M. et Denizeau, F. (2002). Assessing the estrogenic potential of organochlorine pesticides in primary cultures of male rainbow trout (Oncorhynchus mykiss) hepatocytes using vitellogenin as a biomarker. Toxicology, 178(3), 193–207. http://dx.doi.org/10.1016/S0300-483X(02)00228-7.
  • Lord-Fontaine, S. et Averill-Bates, D.A. (2002). Heat shock inactivates cellular antioxidant defenses against hydrogen peroxide: Protection by glucose. Free Radical Biology and Medicine, 32(8), 752–765. http://dx.doi.org/10.1016/S0891-5849(02)00769-4.
  • Okoumassoun, L.-E., Brochu, C., Deblois, C., et al. (2002). Vitellogenin in tilapia male fishes exposed to organochlorine pesticides in Ouémé River in Republic of Benin. Science of the Total Environment, 299(1-3), 163–172. http://dx.doi.org/10.1016/S0048-9697(01)01053-1.
  • Lord-Fontaine, S., Agostinelli, E., Przybytkowski, E. et Averill-Bates, D.A. (2001). Amine oxidase, spermine, and hyperthermia induce cytotoxicity in P-glycoprotein overexpressing multidrug resistant Chinese hamster ovary cells. Biochemistry and cell biology/Biochimie et biologie cellulaire, 79(2), 165–175. http://dx.doi.org/10.1139/bcb-79-2-165.
  • Demers, N., Agostinelli, E., Averill-Bates, D.A. et Fortier, G. (2001). Immobilization of native and poly(ethylene glycol)-treated ('PEGylated') bovine serum amine oxidase into a biocompatible hydrogel. Biotechnology and Applied Biochemistry, 33(3), 201–207. http://dx.doi.org/10.1042/BA20010009.
  • Turcotte, S. et Averill-Bates, D.A. (2001). Sensitization to the cytotoxicity of melphalan by ethacrynic acid and hyperthermia in drug-sensitive and multidrug-resistant chinese hamster ovary cells. Radiation Research, 156(3), 272–282. Récupéré de http://www.jstor.org/stable/3580499.
  • Demeule, M., Laplante, A., Sepehr-Araé, A., et al. (1999). Inhibition of P-glycoprotein by cyclosporin A analogues and metabolites. Biochemistry and cell biology/Biochimie et biologie cellulaire, 77(1), 47–58. http://dx.doi.org/10.1139/bcb-77-1-47.
  • Przybytkowski, E. et Averill-Bates, D.A. (1996). Correlation between glutathione and stimulation of the pentose phosphate cycle in situ in Chinese hamster ovary cells exposed to hydrogen peroxide. Archives of Biochemistry and Biophysics, 325(1), 91–98. http://dx.doi.org/10.1006/abbi.1996.0011.
  • Agostinelli, E., Przybytkowski, E. et Averill-Bates, D.A. (1996). Glucose, glutathione, and cellular response to spermine oxidation products. Free Radical Biology and Medicine, 20(5), 649–656. http://dx.doi.org/10.1016/0891-5849(95)02149-3.
  • Demeule, M., Vachon, V., Delisle, M.-C., et al. (1995). Molecular study of p-glycoprotein in multidrug resistance using surface plasmon resonance. Analytical Biochemistry, 230(2), 239–247. http://dx.doi.org/10.1006/abio.1995.1469.
  • Beaulieu, E., Demeule, M., Pouliot, J.-F., Averill-Bates, D.A., Murphy, G.F. et Beliveau, R. (1995). P-glycoprotein of blood brain barrier: Cross-reactivity of MAb C219 with a 190 kDa protein in bovine and rat isolated brain capillaries. Biochimica et Biophysica Acta (BBA) – Biomembranes, 1233(1), 27–32. http://dx.doi.org/10.1016/0005-2736(94)00239-L.
  • Averill-Bates, D.A. et Courtemanche, B. (1995). The effect of hyperthermia and verapamil on melphalan cytotoxicity and transport in multidrug-resistant Chinese hamster ovary cells. Radiation Research, 143(1), 17–25. http://dx.doi.org/10.2307/3578921.
  • Averill-Bates, D.A., Agostinelli, E., Przybytkowski, E. et Mondovi, B. (1994). Aldehyde dehydrogenase and cytotoxicity of purified bovine serum amine oxidase and spermine in Chinese hamster ovary cells. Biochemistry and cell biology/Biochimie et biologie cellulaire, 72(1-2), 36–42. http://dx.doi.org/10.1139/o94-006.
  • Agostinelli, E., Przybytkowski, E., Mondovi, B. et Averill-Bates, D.A. (1994). Heat enhancement of cytotoxicity induced by oxidation products of spermine in Chinese hamster ovary cells. Biochemical Pharmacology, 48(6), 1181–1186. http://dx.doi.org/10.1016/0006-2952(94)90155-4.
  • Averill-Bates, D.A. et Przybytkowski, E. (1994). The role of glucose in cellular defences against cytotoxicity of hydrogen peroxide in Chinese hamster ovary cells. Archives of Biochemistry and Biophysics, 312(1), 52–58. http://dx.doi.org/10.1006/abbi.1994.1279.
  • Averill-Bates, D.A., Agostinelli, E., Przybytkowski, E., Mateescu, M.A. et Mondovi, B. (1993). Cytotoxicity and kinetic analysis of purified bovine serum amine oxidase in the presence of spermine in Chinese hamster ovary cells. Archives of Biochemistry and Biophysics, 300(1), 75–79. http://dx.doi.org/10.1006/abbi.1993.1011.