Joël Lefebvre

Joël Lefebvre

Professeur
Photo de Joël Lefebvre
Téléphone : (514) 987-3000 poste 3307
Local : PK-4840
Langues : Français, Anglais
Liens d'intérêt
Informations générales

Cheminement académique

2018-2019 - Stage postdoctoral (Big Data Institute, Université d'Oxford)
2014-2018 - Doctorat en génie biomédical (Polytechnique de Montréal)
2012-2014 - Maîtrise en génive biomédical (Polytechnique de Montréal)
2008-2012 - Baccalauréat en génie physique (Polytechnique Montréal)

Unités de recherche

Projets de recherche en cours

Affiliations externes principales

Enseignement

Publications

Articles scientifiques
  • Sjoberg, H.T., Philippou, Y., Magnussen, A.L., Tullis, I.D.C., Bridges, E., Chatrian, A., Lefebvre, J., Tam, K.H., Murphy, E.A., Rittscher, J., Preise, D., Agemy, L., Yechezkel, T., Smart, S.C., Kinchesh, P., Gilchrist, S., Allen, D.P., Scheiblin, D.A., Lockett, S.J., [...] et Bryant, R.J. (2021). Tumour Irradiation Combined with Vascular-Targeted Photodynamic Therapy Enhances Antitumour Effects in Pre-Clinical Prostate Cancer. British Journal of Cancer, 1–13. http://dx.doi.org/10.1038/s41416-021-01450-6.
  • Lefebvre, J., Delafontaine-Martel, P. et Lesage, F. (2019). A Review of Intrinsic Optical Imaging Serial Blockface Histology (ICI-SBH) for Whole Rodent Brain Imaging. Photonics, 6(2), article 66. http://dx.doi.org/10.3390/photonics6020066.
  • Castonguay, A., Lefebvre, J., Pouliot, P. et Lesage, F. (2018). Comparing three-dimensional serial optical coherence tomography histology to MRI imaging in the entire mouse brain. Journal of Biomedical Optics, 23(1), article 016008. http://dx.doi.org/10.1117/1.JBO.23.1.016008.
  • Lefebvre, J., Delafontaine-Martel, P., Pouliot, P., Girouard, H., Descoteaux, M. et Lesage, F. (2018). Fully automated dual-resolution serial optical coherence tomography aimed at diffusion MRI validation in whole mouse brains. Neurophotonics, 5(4), article 045004. http://dx.doi.org/10.1117/1.NPh.5.4.045004.
  • Delafontaine-Martel, P., Lefebvre, J., Tardif, P. L., Lévy, B. I., Pouliot, P. et Lesage, F. (2018). Whole brain vascular imaging in a mouse model of Alzheimer’s disease with two-photon microscopy. Journal of biomedical optics, 23(7), article 076501. http://dx.doi.org/10.1117/1.JBO.23.7.076501.
  • Castonguay, A., Lefebvre,.J., Pouliot, P., Avti, P., Moeini, M. et Lesage, F. (2017). Serial optical coherence scanning reveals an association between cardiac function and the heart architecture in the aging rodent heart. Biomedical Optics Express, 8(11), 5027–5038. http://dx.doi.org/10.1364/BOE.8.005027.
  • Lefebvre, J., Castonguay, A., Pouliot, P., Descoteaux, M. et Lesage, F. (2017). Whole mouse brain imaging using optical coherence tomography: reconstruction, normalization, segmentation, and comparison with diffusion MRI. Neurophotonics, 4(4), article 041501. http://dx.doi.org/10.1117/1.NPh.4.4.041501.
  • Tardif, P.-L., Marie-Jeanne Bertrand, M.-J., Abran, M., Castonguay, A., Lefebvre, J., Stähli, B. E.,... Lesage, F. (2016). Validating intravascular imaging with serial optical coherence tomography and confocal fluorescence microscopy. International Journal of Molecular Sciences, 17(12), article 2110. http://dx.doi.org/10.3390/ijms17122110.
  • Gagnon, L., Sakadžić, S., Lesage, F., Musacchia, J.J., Lefebvre, J., Fang, Q.,... Boas, D. A. (2015). Quantifying the microvascular origin of BOLD-fMRI from first principles with two-photon microscopy and an oxygen-sensitive nanoprobe. The Journal of Neuroscience, 35(8), 3663–3675. http://dx.doi.org/10.1523/JNEUROSCI.3555-14.2015.
  • Desjardin, M., Berti, R., Lefebvre, J., Dubeau, S. et Lesage, F. (2014). Aging-related differences in cerebral capillary blood flow in anesthetized rats. Neurobiology of Aging, 35(8), 1947–1955. http://dx.doi.org/10.1016/j.neurobiolaging.2014.01.136.
  • Sakadžić, S., Mandeville, E.T., Gagnon, L., Musacchia, J.J., Yaseen, M.A., Yucel, M. A., Lefebvre, J.,... Boas, D.A. (2014). Large arteriolar component of oxygen delivery implies a safe margin of oxygen supply to cerebral tissue. Nature Communications, 5, article 5734. http://dx.doi.org/10.1038/ncomms6734.
Actes de colloque
  • Lefebvre, J., Delafontaine-Martel, P., Lemieux, P., Descoteaux, M., Petit, L. et Lesage, F. (2021). Localization and Imaging of White Matter Fiber Crossings in Whole Mouse Brains Using Diffusion MRI and Serial Blockface OCT. Dans Q. Luo, J. Ding et L. Fu (dir.). Optical Techniques in Neurosurgery, Neurophotonics, and Optogenetics, SPIE. http://dx.doi.org/10.1117/12.2577648.
  • Delas Peñas, K., Dmitrieva, M., Lefebvre, J., Zenner, H., Allgeyer, E., Booth, M., St. Johnston, D. et Rittscher, J. (2020). Extracting Axial Depth and Trajectory Trend Using Astigmatism, Gaussian Fitting, and CNNs for Protein Tracking. Dans 2020 IEEE 17th International Symposium on Biomedical Imaging (ISBI), 1634‑1637. Iowa City, IA, USA: IEEE. http://dx.doi.org/10.1109/ISBI45749.2020.9098364.
  • Dmitrieva, M., Lefebvre, J., Delas Peñas, K., Zenner, H.L., Richens, J., St. Johnston, D. et Rittscher, J. (2020). Short Trajectory Segmentation with 1D UNET Framework: Application to Secretory Vesicle Dynamics. Dans 2020 IEEE 17th International Symposium on Biomedical Imaging (ISBI), 891‑894. Iowa City, IA, USA: IEEE. http://dx.doi.org/10.1109/ISBI45749.2020.9098426.
  • Lefebvre, J., Javer, A., Dmitrieva, M., Rittscher, J., Lewkow, B., Allgeyer, E., Sirinakis, G. et St. Johnston, D. (2020). Single-Molecule Localization Microscopy Reconstruction Using Noise2Noise for Super-Resolution Imaging of Actin Filaments. Dans 2020 IEEE 17th International Symposium on Biomedical Imaging (ISBI), 1596‑1599. Iowa City, IA, USA: IEEE. http://dx.doi.org/10.1109/ISBI45749.2020.9098713.
  • Lefebvre, J., Castonguay, A. et Lesage, F. (2018). Imaging Whole Mouse Brains with a Dual Resolution Serial Swept-Source Optical Coherence Tomography Scanner. Dans Q. Luo et J. Ding (dir.). Neural Imaging and Sensing 2018, 12. San Francisco, United States: SPIE. http://dx.doi.org/10.1117/12.2288521.
  • Delafontaine-Martel, P., Lesage, F., Damseh, R., Lefebvre, J., Castonguay, A. et Tardif, P.-L. (2018). Large Scale Serial Two-Photon Microscopy to Investigate Local Vascular Changes in Whole Rodent Brain Models of Alzheimer’s Disease. Dans A. Periasamy, P.T. So, X.S. Xie et K. König (dir.). Multiphoton Microscopy in the Biomedical Sciences XVIII, 92. San Francisco, United States: SPIE. http://dx.doi.org/10.1117/12.2290060.
  • Lefebvre, J., Castonguay, A. et Lesage, F. (2017). White matter segmentation by estimating tissue optical attenuation from volumetric OCT massive histology of whole rodent brains. Dans Three-Dimensional and Multidimensional Microscopy: Image Acquisition and Processing XXIV, 10070:1007012. International Society for Optics and Photonics. http://dx.doi.org/10.1117/12.2251173.
  • Lesage, F., Castonguay, A., Tardif, P.-L., Lefebvre, J. et Li, B. (2015). Investigating the Impact of Blood Pressure Increase to the Brain Using High Resolution Serial Histology and Image Processing. Dans M. Papadakis, V.K. Goyal et D. Van De Ville (dir.). Wavelets and Sparsity XVI, 95970M. San Diego, California, United States. http://dx.doi.org/10.1117/12.2189110.
  • Gagnon, L., Sakadžić, S., Lesage, F., Musacchia, J.J., Lefebvre, J., Fang, Q., Yücel, M.A., Evans, K.C., Mandeville, E.T., Cohen-Adad, J., Polimeni, J.R., Yaseen, M.A., Lo, E.H., Greve, D.N., Buxton, R.B., Dale, A.M., Devor, A. et Boas, D.A. (2014). Folded cortical orientation influences the amplitude of BOLD-fMRI: evidence from simulations and experimental data. Dans Proc. Intl. Soc. Mag. Reson. Med., 22, article 3084.
  • Sakadžić, S., Mandeville, E.T., Gagnon, L., Musacchia, J.J., Yaseen, M.A., Yucel, M.A., Lefebvre, J., Lesage, F., Dale, A.M., Eikermann-Haerter, K., Ayata, C., Srinivasan, V.J., Lo, E.H., Devor, A. et Boas, D.A. (2014). High-Resolution Optical Microscopy Imaging of Cortical Oxygen Delivery and Consumption. Dans CLEO: 2014, AF2B.3. San Jose, California: OSA. http://dx.doi.org/10.1364/CLEO_AT.2014.AF2B.3.
  • Desjardins, M., Berti, R., Lefebvre, J., Dubeau, S. et Lesage, F. (2014). Microscopic Dynamics of Cerebral Capillary Blood Flow in Aged Anesthetized Rats. Dans Biomedical Optics 2014, BT3A.3. Miami, Florida: OSA. http://dx.doi.org/10.1364/BIOMED.2014.BT3A.3.
  • Sakadžić, S., Mandeville, E.T., Gagnon, L., Musacchia, J.J., Yaseen, M.A., Yucel, M.A., Lefebvre, J., Lesage, F., Dale, A.M., Eikermann-Haerter, K., Ayata, C., Srinivasan, V.J., Lo, E.H., Devor, A. et Boas, D.A. (2014). Oxygen Distribution in Cortical Microvasculature Reveals a Novel Mechanism for Maintaining a Safe Tissue Oxygenation. Dans Biomedical Optics 2014, BW1A.2. Miami, Florida: OSA. http://dx.doi.org/10.1364/BIOMED.2014.BW1A.2.
  • Gagnon, L., Sakadžić, S., Lesage, F., Musacchia, J.J., Lefebvre, J., Fang, Q., Yücel, M.A., Evans, K.C., Mandeville, E.T., Cohen-Adad, J., Polimeni, J.R., Yaseen, M.A., Lo, E.H., Greve, D.N., Buxton, R.B., Dale, A.M., Devor, A. et Boas, D.A. (2014). Underpinning the Microvascular Origin of BOLD-FMRI with Two-Photon Microscopy. Dans Biomedical Optics 2014, BT4A.1. Miami, Florida: OSA. http://dx.doi.org/10.1364/BIOMED.2014.BT4A.1.