Marc Lussier

Marc Lussier

Professeur
Photo de Marc Lussier
Liens d'intérêt
Informations générales

Cheminement académique

-Professeur, Département de chimie, UQAM, 2014-aujourd'hui
-Stage postdoctoral, National Institute of Neurological Diseases and Stroke, 2008-2014
-PhD en pharmacologie, Université de Sherbrooke, 2001-2008
-BSc en biologie médicale, Université du Québec à Trois-Rivières, 1998-2001

Unités de recherche

  • Centre de recherche sur la conception, les mécanismes d'action et la vectorisation des médicaments (PharmaQAM)
  • Centre de recherches biomédicales (BIOMED)
Enseignement
Distinctions
  • Bourse de formation postdoctorale - Fonds de recherche du Québec - Santé (2009-2012)
  • Bourse de recherche au doctorat - Fondation des maladies du coeur du Canada (2006-2008)
  • Mention d'honneur du Doyen, Faculté de Médecine et des Sciences de la Santé de Sherbrooke, Université de Sherbrooke (2005)).
Services à la collectivité

Membre du Comité institutionnel de protection des animaux (CIPA); 2015 - aujourd'hui.

Directions de thèses et mémoires

Mémoires

Publications

Articles scientifiques
  • Gu, X., Mao, X., Lussier, M.P., et al. (2016). GSG1L suppresses AMPA receptor-mediated synaptic transmission and uniquely modulates AMPA receptor kinetics in hippocampal neurons. Nature Communications. http://dx.doi.org/10.1038/ncomms10873.
    Notes: Publication sous presse
  • Lussier, M.P., Sanz-Clemente, A. et Roche, K.W. (2015). Dynamic regulation of NMDA and AMPA receptors by posttranslational modifications. The Journal of Biological Chemistry, 29(48), 28596–28603. http://dx.doi.org/10.1074/jbc.R115.652750.
  • Lussier, M.P., Gu, X., Lu, W. et Roche, K.W. (2014). Casein Kinase 2 phosphorylates GluA1 and regulates its surface expression. European Journal of Neuroscience, 39(7), 1148–1158. http://dx.doi.org/10.1111/ejn.12494.
  • Lussier, M.P., Herring, B.E., Nasu-Nishimura, Y., Neutzner, A., et al. (2012). Ubiquitin ligase RNF167 regulates AMPA receptor-mediated synaptic transmission. Proceedings of the National Academy of Sciences of the United States of America, 109(47), 19426–19431. http://dx.doi.org/10.1073/pnas.1217477109.
  • Lussier, M.P., Nasu-Nishimura, Y. et Roche, K.W. (2011). Activity-dependent ubiquitination of the AMPA receptor subunit GluA2. The Journal of neuroscience : the official journal of the Society for Neuroscience, 31(8), 3077–3081. http://dx.doi.org/10.1523/JNEUROSCI.5944-10.2011.
  • Mace, K.E., Lussier, M.P., Boulay, G., et al. (2010). TRUSS, TNF-R1, and TRPC ion channels synergistically reverse endoplasmic reticulum Ca2+ storage reduction in response to m1 muscarinic acetylcholine receptor signaling. Journal of cellular physiology, 225(2), 444–453. http://dx.doi.org/10.1002/jcp.22221.
  • Lepage, P.K., Lussier, M.P. et McDuff, F.O., Lavigne, P., Boulay, G. (2009). The self-association of two N-terminal interaction domains plays an important role in the tetramerization of TRPC4. Cell calcium, 45(3), 251–259. http://dx.doi.org/10.1016/j.ceca.2008.11.002.
  • Lussier, M.P., Lepage, P.K., Bousquet, S.M. et Boulay, G. (2008). RNF24, a new TRPC interacting protein, causes the intracellular retention of TRPC. Cell Calcium, 43(5), 432–443. http://dx.doi.org/10.1016/j.ceca.2007.07.009.
  • Lepage, P.K., Lussier, M.P., Barajas-Martinez, H., et al. (2006). Identification of two domains involved in the assembly of transient receptor potential canonical channels. The Journal of Biological Chemistry, 281(41), 30356–30364. http://dx.doi.org/10.1074/jbc.M603930200.
  • Lussier, M.P., Cayouette, S., Lepage, P.K., et al. (2005). MxA, a member of the dynamin superfamily, interacts with the ankyrin-like repeat domain of TRPC. Journal of Biological Chemistry, 280(19), 19393–19400. http://dx.doi.org/10.1074/jbc.M500391200.
  • Lessard, C.B., Lussier, M.P., Cayouette, S., Bourque, G. et Boulay, G. (2005). The overexpression of presenilin2 and Alzheimer's-disease-linked presenilin2 variants influences TRPC6-enhanced Ca2+ entry into HEK293 cells. Cellular signalling, 17(4), 437–445. http://dx.doi.org/10.1016/j.cellsig.2004.09.005.
  • Cayouette, S., Lussier, M.P., Mathieu, E.L., Bousquet, S.M. et Boulay, G. (2004). Exocytotic insertion of TRPC6 channel into the plasma membrane upon Gq protein-coupled receptor activation. Journal of Biological Chemistry, 279(8), 7241–7246. http://dx.doi.org/10.1074/jbc.M312042200.
Actes de colloque
  • Gu, X., Mao, X., Lussier, M.P., et al. (2015). The role of GSG1L in the regulation of AMPA receptor-mediated synaptic transmission. Dans Society for Neurosciences, Chicago, 2015-10-18.
    Notes: Affiche
  • Gu, X., Lussier, M.P., Mao, X., et al. (2014). GSG1L negatively regulates excitatory synaptic transmission and is required for non-spatial object memory. Dans Synaptic Transmission Gordon Research Conference, Waterville Valley, 2014-08-03.
    Notes: Affiche
  • Lussier, M.P., Herring, B.E., Youle, R.J., Nicoll, R.A. et Roche, K.W. (2012). The ubiquitin ligase RNF167 regulates AMPA receptor-mediated synaptic transmission. Dans Society for Neurosciences, New Orleans, 2012-10-13.
    Notes: Affiche
  • Lussier, M.P., Herring, B.E., Nasu-Nishimura, Y., et al. (2011). Regulation of AMPA receptors by a novel membrane-spanning RING-domain containing E3-ligase, RNF167. Dans Society for Neurosciences, Washington, 2011-11-12.
    Notes: Affiche
  • Lussier, M.P., Herring, B.E., Youle, R.J., Nicoll, R.A. et Roche, K.W. (2011). Regulation of AMPA receptors by a novel membrane-spanning RING-domain containing E3-ligase, RNF167. Dans Excitatory Synapses and Brain Function. Gordon Research Conference, Easton, 2011-06-26.
    Notes: Affiche
  • Lussier, M.P. et Roche, K.W. (2010). Activity-dependent ubiquitinylation and degradation of the AMPA receptor subunit GluA2. Dans Cell Biology of the Neuron, Gordon Research Conference., Waterville Valley, 2010-06-27.
    Notes: Affiche
  • Lussier, M.P. et Roche, K.W. (2010). Activity-dependent ubiquitinylation and degradation of the AMPA receptor subunit GluA2. Dans Society for Neuroscience, Program No. 237.11., San Diego, 2010-11-13.
    Notes: Affiche
  • Lussier, M.P., Lepage, P.K. et Boulay, G. (2007). TRPCs interact with RNF24 at the level of the Golgi apparatus. Dans The Faseb Journal, Washington.
    Notes: Affiche
  • Lussier, M.P., Cayouette, S., Lepage, P.K. et Boulay, G. (2005). MxA Interacts with and Regulates the Activity of the TRPC6 Channel. Dans Experimental Biology 2005 and XXXV International Congress of Physiological Sciences, San Diego.
    Notes: Affiche
  • Boulay, G., Cayouette, S., Lussier, M.P., Mathieu, E.-L. et Bousquet, S. (2003). An Externalisation of TRPC6 is Concomittant with the Carbachol-Induced Calcium Entry in HEK-293 cells. Dans Calcium Signaling Gordon Research Conferences, South Hadley, 2003-07-06.
    Notes: Affiche
  • Cayouette, S., Lussier, M.P., Mathieu, E.-L., Bousquet, S. et Boulay, G. (2003). Externalisation of TRPC6 Upon Gq-Protein Coupled Receptor Activation in HEK-293 Cells. Dans 43rd Annual Meeting of the American Society for Cell Biology, San Francisco, 2003-12-13.
    Notes: Affiche
  • Lepage, P.K., Lussier, M.P., Blanchard, A.P., Bernier, C.L., Cayouette, S. et Boulay, G. Identification of the Region Responsible for the Tetramerization of TRPC4 Channel. Dans Experimental Biology 2005 and XXXV International Congress of Physiological Sciences, San Diego.
    Notes: Affiche
  • Lussier, M.P., Pinard, M., St-Hilaire, M., Francoeur, N., Cayouette, S. et Boulay, G. Identification of Two Proteins Interacting Specifically with the Ankyrin Repeat Domain of TRPC6. Dans 43rd Annual Meeting of the American Society for Cell Biology, San Francisco.
    Notes: Affiche
  • Boulay, G., Lepage, P.K., Lussier, M.P., et al. Implication of the N-terminal and pore region of TRPC in the channel assembly. Dans Biochemical Society Focused Meeting – Cell and Molecular Biology of TRP Channels, Bath.
    Notes: Affiche
  • Boulay, G., Lessard, C.B., Lussier, M.P. et Cayouette, S. Presenilin 2 and its Alzheimer's Disease-Linked Mutants Inhibit Agonist-Induced TRPC6 Activation. Dans FASEB Summer Research Conference on Calcium and Cell Function, Snowmass Village.
    Notes: Affiche
Autres publications
  • Gu, X., Lussier, M.P., Mao, X., et al. GSG1L inhibits excitatory synaptic transmission and speeds up AMPA receptor kinetic properties in neurons.