Isabelle Marcotte

Isabelle Marcotte

Professeure
Photo de Isabelle Marcotte
Téléphone : (514) 987-3000 poste 5015
Local : CB-3140
Langues : Français, Anglais
Liens d'intérêt
Informations générales

Cheminement académique

Études postdoctorales - ETH de Zürich (2003-2006)
Doctorat en chimie - Université Laval (1998-2003)
Maîtrise en chimie - Université de Montréal (1994-1997)
Baccalauréat en chimie - Université du Québec à Rimouski (1991-1994)

Unités de recherche

  • Centre de recherche sur la conception, les mécanismes d'action et la vectorisation des médicaments (PharmaQAM)
  • Centre de recherche sur les nanomatériaux et l'énergie (NanoQAM)

Partenaires (organismes, entreprises)

  • Corealis Pharma inc., Merinov, La Moule du Large inc., SCF Pharma Inc., MInicstère des Pêches et Océans Canada.

Affiliations externes principales

Enseignement
Communications
Distinctions
  • 2014 - Prix Relève en Recherche de la Faculté des Sciences de l'UQAM
  • 2012 - Travaux sur le byssus de la moule parmi les 50 défis à relever d'ici 2050 d'après Québec Science (Octobre 2012)

Directions de thèses et mémoires

Thèses de doctorat
Mémoires

Publications

Articles scientifiques
  • Warnet, X.L., Laadhari, M., Arnold, A.A., Marcotte, I. et Warschawski, D.E. (2016). A 2H magic-angle spinning solid-state NMR characterisation of lipid membranes in intact bacteria. Biochimica et Biophysica Acta, 1858(1), 146–152. http://dx.doi.org/10.1016/j.bbamem.2015.10.020.
  • Warnet, X.L., Arnold, A.A., Marcotte, I. et Warschawski, D.E. (2015). In cell solid-state NMR: an emerging technique for the study of biological membranes. Biophysical Journal, 109(12), 2461–2466. http://dx.doi.org/10.1016/j.bpj.2015.10.041.
  • Arnold, A.A., Genard, B., Warschawski, D.E., Zito, F., Tremblay, R. et Marcotte, I. (2014). Identification of lipid and saccharide constituents of whole microalgal cells by 13C solid-state NMR. Biochimica et biophysica acta – Biomembranes, 1858, 369–377. http://dx.doi.org/10.1016/j.bbamem.2014.07.017.
  • Seguin-Heine, M.-O., Lachance, A.-A., Genard, B., et al. (2014). Impact of open-sea habitat on byssus attachment of suspension-cultured blue mussels (Mytilus edulis). Aquaculture, 426-427, 189–196. http://dx.doi.org/10.1016/j.aquaculture.2014.02.006.
  • Beaugrand, M., Arnold, A.A., Hénin, J., Warschawski, D.E., Williamson, P.T.F. et Marcotte, I. (2014). Lipid concentration and molar ratio boundaries for the use of isotropic bicelles. Langmuir, 30(21), 6162–6170. http://dx.doi.org/10.1021/la5004353.
  • Gastineau, R., Turcotte, F., Pouvreau, J.-B., et al. (2014). Marennine, Promising Blue Pigments from a Widespread Haslea Diatom Species Complex. Marine Drugs, 12(6), 3161–3189. http://dx.doi.org/10.3390/md12063161.
  • Byette, F., Pellerin, C. et Marcotte, I. (2014). Self-assembled pH-responsive films prepared from mussel anchoring threads. Journal of materials chemistry B, 2(37), 6378–6386. http://dx.doi.org/10.1039/C4TB01021C.
  • Tardy-Laporte, C., Arnold, A.A., Génard, B., et al. (2013). A 2H solid-state NMR study of effect of antimicrobials on intact Escherichia coli without mutating. Biochimica et biophysica acta – Biomembranes, 1828(2), 614–622. http://dx.doi.org/10.1016/j.bbamem.2012.09.011.
  • Gravel, A., Arnold, A.A., Dufourc, E.J. et Marcotte, I. (2013). An NMR investigation of the structure, function and role of the hERG channel selectivity filter in the long QT syndrome. Biochimica et biophysica acta, 1828(6), 1494–1502. http://dx.doi.org/10.1016/j.bbamem.2013.02.012.
  • Friddin, M.S., Smithers, N.P., Beaugrand, M., et al. (2013). Single-channel electrophysiology of cell-free expressed ion channels by direct incorporation in lipid bilayers. Analyst, 138(24), 7294–7298. http://dx.doi.org/10.1039/C3AN01540H.
  • Arnold, A.A., Byette, F., Séguin-Heine, M.-O., et al. (2013). Solid-state NMR structure determination of whole anchoring threads from the blue mussel Mytilus edulis. Biomacromolecules, 14(1), 132–141. http://dx.doi.org/10.1021/bm301493u.
  • Arnold, A.A., Terskikh, V., Naccache, R., Marcotte, I. et Capobianco, J.A. (2013). Structure of NaYF4 upconverting nanoparticles: a multinuclear solid-state NMR and DFT computational study. The journal of physical chemistry C, 117(48), 25733–25741. http://dx.doi.org/10.1021/jp405813a.
  • Hennebicq, R., Fabra, G., Pellerin, C., Marcotte, I., Myrand, B. et Tremblay, R. (2013). The effect of spawning of cultured mussels (Mytilus edulis) on mechanical properties, chemical and biochemical composition of byssal threads. Aquaculture, 410-411, 11–17. http://dx.doi.org/10.1016/j.aquaculture.2013.06.011.
  • Brisebois, P.P., Arnold, A.A., Chabre, Y.M., Roy, R. et Marcotte, I. (2012). Comparative study of the interaction of fullerenol nanoparticles with eukaryotic and bacterial model membranes using solid-state NMR and FTIR spectroscopy. European Biophysics Journal, 41(6), 535–544. http://dx.doi.org/10.1007/s00249-012-0809-5.
  • Leblanc, A., Arnold, A.A., Nadalini, J.-B., et al. (2012). Determination of isotopic labeling of proteins by precursor ion scanning liquid chromatography/tandem mass spectrometry of derivatized amino acids applied to nuclear magnetic resonance studies. Rapid Communications in Mass Spectrometry, 26(10), 1165–1174. http://dx.doi.org/10.1002/rcm.6204.
  • Nirasay, S., Badia, A., Leclair, G., Claverie, J.P. et Marcotte, I. (2012). Polydopamine-supported lipid bilayers. Materials, 5(12), 2621–2636. http://dx.doi.org/10.3390/ma5122621.
  • Lachance, A.-A., Hennebicq, R., Myrand, B., et al. (2011). Biochemical and genetic characteristics of suspension-cultured mussels (Mytilus edulis) in relation to byssal thread production and losses by fall-off. Aquatic Living Resource, 24(3), 283–293. http://dx.doi.org/10.1051/alr/2011115.
  • Byette, F., Bouchard, F., Pellerin, C., Paquin, J., Marcotte, I. et Mateescu, M.A. (2011). Cell-culture compatible silk fibroin scaffolds concomitantly patterned by freezing conditions and salt concentration. Polymer Bulletin, 67(1), 159–175. http://dx.doi.org/10.1007/s00289-010-0438-z.
  • Warschawski, D.E., Arnold, A.A., Beaugrand, M., Gravel, A., Chartrand, E. et Marcotte, I. (2011). Choosing membrane mimetics for NMR structural studies of transmembrane proteins. Biochimica et biophysica acta, 1808(8), 1957–1974. http://dx.doi.org/10.1016/j.bbamem.2011.03.016.
  • Chabre, Y., Brisebois, P., Abbasi, L., et al. (2011). Hexaphenylbenzene as a Rigid Template for the Straightforward Syntheses of "Star-Shaped" Glycodendrimers. Journal of organic chemistry, 76(2), 724–727. http://dx.doi.org/10.1021/jo102215y.
  • Nirasay, S., Mouget, Y., Marcotte, I. et Claverie J. P. (2011). Supported bilayer on a nanopatterned membrane as model PAMPA membranes. International Journal of Pharmaceutics, 421(1), 170–175. http://dx.doi.org/10.1016/j.ijpharm.2011.09.013.
  • Larocque, G., Arnold, A.A., Chartrand, É., Mouget, Y. et Marcotte, I. (2010). Effect of Sodium Bicarbonate as a Pharmaceutical Formulation Excipient on the Interaction of Fluvastatin with Membrane Phospholipids. European Biophysics Journal, 39(12), 1637–1647. http://dx.doi.org/10.1007/s00249-010-0622-y.
  • Chartrand, É., Arnold, A.A., Gravel, A., Jenna, S. et Marcotte, I. (2010). Potential role of the membrane in the hERG channel functioning and drug-induced long QT syndrome. Biochimica et biophysica acta, 1798(9), 1651–1662. http://dx.doi.org/10.1016/j.bbamem.2010.05.019.
  • Arnold, A.A. et Marcotte, I. (2009). Studying natural structural protein fibers by solid-state nuclear magnetic resonance. Concepts in Magnetic Resonance Part A, 34A(1), 24–47. http://dx.doi.org/10.1002/cmr.a.20132.
  • Marcotte, I., Van Beek, J.D. et Meier, B.H. (2007). Molecular order and structure of spider dragline silk investigated by two-dimensional solid-state NMR spectroscopy. Macromolecules, 40(26), 1995–2001. http://dx.doi.org/10.1021/ma062452n.
  • Marcotte, I., Belanger, A. et Auger, M. (2006). The orientation effect of gramicidin A on bicelles and Eu3+-doped bicelles as studied by solid-state NMR and FTIR spectroscopy. Chemistry and physics of lipids, 139(2), 137–149. http://dx.doi.org/10.1016/j.chemphyslip.2005.12.002.
  • Marcotte, I. et Auger, M. (2005). Bicelles as model membranes for solid- and solution-state NMR studies of membrane peptides and proteins. Concepts in Magnetic Resonance Part A, 24A(1), 17–37. http://dx.doi.org/10.1002/cmr.a.20025.
  • Marcotte, I., Auger, M., Separovic, F. et Gagné, S.M. (2004). A Multidimensional 1H NMR Investigation of the Conformation of Methionine-Enkephalin in Fast-Tumbling Bicelles. Biophysical Journal, 86(3), 1587–1600. http://dx.doi.org/10.1016/S0006-3495(04)74226-5.
  • Marcotte, I., Ouellet, M. et Auger, M. (2004). Insights on the Interaction of Met-Enkephalin with Negatively Charged Membranes: an Infrared and Solid-Sate NMR Spectroscopic Study. Chemistry and physics of lipids, 127(2), 175–187. http://dx.doi.org/10.1016/j.chemphyslip.2003.10.012.
  • Marcotte, I., Wegener, K., Lam, Y.-H., et al. (2003). Interaction of Antimicrobial Peptides from Australian Amphibians with Lipid Membranes. Chemistry and physics of lipids, 122(1-2), 107–120. http://dx.doi.org/10.1016/S0009-3084(02)00182-2.
  • Marcotte, I., Dufourc, E.J., Ouellet, M. et Auger, M. (2003). Interaction of the Neuropeptide Met-Enkephalin with Zwitterionic and Negatively Charged Bicelles as Viewed by 31P and 2H Solid-State NMR. Biophysical Journal, 85(1), 328–339. http://dx.doi.org/10.1016/S0006-3495(03)74477-4.
  • Paul, G.J.C., Marcotte, I., Anastassopoulou, J., Arkas, M., Paleos, C.M. et Bertrand, M.J. (1996). An investigation of the clustering processes occurring in liquid-assisted secondary ion mass spectrometry for alkyl quaternary ammonium bromides. Journal of mass spectrometry, 31(1), 95–100. http://dx.doi.org/10.1002/(SICI)1096-9888(199601)31:1<95::AID-JMS275>3.0.CO;2-V.
Chapitres de livre
  • Marcotte, I. et Booth, V. (2014). 2H solid-state NMR study of peptide-membrane interactions in intact bacteria. Dans F. Separovic et A. Naito (dir.). Advances in Biological Solid-State NMR: Proteins and Membrane-Active Peptides. Cambridge : Royal Society of Chemistry.
    Notes: collection New Developments in NMR
  • Lefèvre, T., Byette, F., Marcotte, I. et Auger, M. (2014). Protein- and peptide-based materials: a source of inspiration for innovation. Dans R. Gauvin et M. Leclerc (dir.). Functional materials for energy, sustainable development and biomedical sciences. Berlin : De Gruyter.