Isabelle Marcotte

Isabelle Marcotte

Professeure
Photo de Isabelle Marcotte
Téléphone : (514) 987-3000 poste 5015
Local : CB-3140
Langues : Français, Anglais
Liens d'intérêt
Informations générales

Cheminement académique

Études postdoctorales - ETH de Zürich (2003-2006)
Doctorat en chimie - Université Laval (1998-2003)
Maîtrise en chimie - Université de Montréal (1994-1997)
Baccalauréat en chimie - Université du Québec à Rimouski (1991-1994)

Unités de recherche

  • Centre de recherche sur la conception, les mécanismes d'action et la vectorisation des médicaments (PharmaQAM)
  • Centre de recherche sur les nanomatériaux et l'énergie (NanoQAM)

Partenaires (organismes, entreprises)

  • Corealis Pharma inc., Merinov, La Moule du Large inc., SCF Pharma Inc., MInicstère des Pêches et Océans Canada.

Affiliations externes principales

Enseignement
Communications
Distinctions
  • 2014 - Prix Relève en Recherche de la Faculté des Sciences de l'UQAM
  • 2012 - Travaux sur le byssus de la moule parmi les 50 défis à relever d'ici 2050 d'après Québec Science (Octobre 2012)

Directions de thèses et mémoires

Thèses de doctorat
Mémoires

Publications

Articles scientifiques
  • Yan, X., Noël, F., Marcotte, I., DeWolf, C.E., Warschawski, D.E. et Boisselier, E. (2020). AHNAK C-Terminal Peptide Membrane Binding-Interactions Between the Residues 5654-5673 of AHNAK and Phospholipid Monolayers and Bilayers. Langmuir, 36, 362–369. http://dx.doi.org/10.1021/acs.langmuir.9b02973.
  • Byette, F., Marcotte, I. et Pellerin, C. (2019). Covalently crosslinked mussel byssus protein-based materials with tunable properties. Peptide Science, 111(1), e24053. http://dx.doi.org/10.1002/pep2.24053.
  • Sebastiao, M., Quittot, N., Marcotte, I. et Bourgault, S. (2019). Glycosaminoglycans Induce Amyloid Self-Assembly of a Peptide Hormone by Concerted Secondary and Quaternary Conformational Transitions. Biochemistry, 58(9), 1214–1225. http://dx.doi.org/10.1021/acs.biochem.8b01206.
  • Bouhlel, Z., Arnold, A.A., Warschawski, D.E., Lemarchand, K., Tremblay, R. et Marcotte, I. (2019). Labelling strategy and membrane characterization of marine bacteria Vibrio splendidus by in vivo 2H NMR. Biochimica et Biophysica Acta – Biomembranes, 1861(4), 871–878. http://dx.doi.org/10.1016/j.bbamem.2019.01.018.
  • Warschawski, D.E., Arnold, A.A. et Marcotte, I. (2018). A New Method of Assessing Lipid Mixtures by 31P Magic-Angle Spinning NMR. Biophysical Journal, 114(6), 1368–1376. http://dx.doi.org/10.1016/j.bpj.2018.01.025.
  • Poulhazan, A., Arnold, A., Warschawski, D. et Marcotte, I. (2018). Unambiguous Ex Situ and in Cell 2D 13C Solid-State NMR Characterization of Starch and Its Constituents. International Journal of Molecular Sciences, 19(12), 3817. http://dx.doi.org/10.3390/ijms19123817.
  • Arnold, A.A., Bourgouin, J.-P., Genard, B., Warschawski, D.E., Tremblay, R. et Marcotte, I. (2018). Whole cell solid-state NMR study of Chlamydomonas reinhardtii microalgae. Journal of Biomolecular NMR, 70, 123–131. http://dx.doi.org/10.1007/s10858-018-0164-7.
  • Beaugrand, M., Arnold, A.A., Bourgault, S., Williamson, P.T.F. et Marcotte, I. (2017). Comparative study of the structure and interaction of the pore helices of the hERG and Kv1.5 potassium channels in model membranes. European Biophysics Journal, 46(6), 549–559. http://dx.doi.org/10.1007/s00249-017-1201-2.
  • Bouhlel, Z., Genard, B., Ibrahim, N., Carrington, E., Babarro, J.M.F., Lok, A.,...Marcotte, I. (2017). Interspecies comparison of the mechanical properties and biochemical composition of byssal threads. The Journal of Experimental Biology, 220(6), 984–994. http://dx.doi.org/10.1242/jeb.141440.
  • Booth, V., Warschawski, D.E., Santisteban, N.P., Laadhari, M. et Marcotte, I. (2017). Recent progress on the application of 2 H solid-state NMR to probe the interaction of antimicrobial peptides with intact bacteria. Biochimica et Biophysica Acta – Proteins and Proteomics, 1865(11), 1500–1511. http://dx.doi.org/10.1016/j.bbapap.2017.07.018.
  • Warnet, X.L., Laadhari, M., Arnold, A.A., Marcotte, I. et Warschawski, D.E. (2016). A 2H magic-angle spinning solid-state NMR characterisation of lipid membranes in intact bacteria. Biochimica et Biophysica Acta – Biomembranes, 1858(1), 146–152. http://dx.doi.org/10.1016/j.bbamem.2015.10.020.
  • Laadhari, M., Arnold, A.A., Gravel, A.E., Separovic, F. et Marcotte, I. (2016). Interaction of the antimicrobial peptides caerin 1.1 and aurein 1.2 with intact bacteria by 2 H solid-state NMR. Biochimica et Biophysica Acta – Biomembranes, 1858(12), 2959–2964. http://dx.doi.org/10.1016/j.bbamem.2016.09.009.
  • Beaugrand, M., Arnold, A.A., Juneau, A., Gambaro, A.B., Warschawski, D.E., Williamson, P.T.F. et Marcotte, I. (2016). Magnetically Oriented Bicelles with Monoalkylphosphocholines: Versatile Membrane Mimetics for Nuclear Magnetic Resonance Applications. Langmuir, 32(49), 13244–13251. http://dx.doi.org/10.1021/acs.langmuir.6b03099.
  • Byette, F., Laventure, A., Marcotte, I. et Pellerin, C. (2016). Metal–Ligand Interactions and Salt Bridges as Sacrificial Bonds in Mussel Byssus-Derived Materials. Biomacromolecules, 17(10), 3277–3286. http://dx.doi.org/10.1021/acs.biomac.6b01010.
  • Ng, C.-A., Gravel, A.E., Perry, M.D., Arnold, A.A., Marcotte, I. et Vandenberg, J.I. (2016). Tyrosine Residues from the S4-S5 Linker of Kv11.1 Channels Are Critical for Slow Deactivation. Journal of Biological Chemistry, 291(33), 17293–17302. http://dx.doi.org/10.1074/jbc.M116.729392.
  • Warnet, X.L., Arnold, A.A., Marcotte, I. et Warschawski, D.E. (2015). In cell solid-state NMR: an emerging technique for the study of biological membranes. Biophysical Journal, 109(12), 2461–2466. http://dx.doi.org/10.1016/j.bpj.2015.10.041.
  • Arnold, A.A., Genard, B., Warschawski, D.E., Zito, F., Tremblay, R. et Marcotte, I. (2014). Identification of lipid and saccharide constituents of whole microalgal cells by 13C solid-state NMR. Biochimica et biophysica acta – Biomembranes, 1858, 369–377. http://dx.doi.org/10.1016/j.bbamem.2014.07.017.
  • Seguin-Heine, M.-O., Lachance, A.-A., Genard, B., Myrand, B., Pellerin, C., Marcotte, I. et Tremblay, R. (2014). Impact of open-sea habitat on byssus attachment of suspension-cultured blue mussels (Mytilus edulis). Aquaculture, 426-427, 189–196. http://dx.doi.org/10.1016/j.aquaculture.2014.02.006.
  • Beaugrand, M., Arnold, A.A., Hénin, J., Warschawski, D.E., Williamson, P.T.F. et Marcotte, I. (2014). Lipid concentration and molar ratio boundaries for the use of isotropic bicelles. Langmuir, 30(21), 6162–6170. http://dx.doi.org/10.1021/la5004353.
  • Gastineau, R., Turcotte, F., Pouvreau, J.-B., Morançais, M., Fleurence, J., Windarto, E., Prasetiya, F.S., Arsad, S., Babin, M., Coiffard, L., Couteau, C., Bardeau, J.-F., Jacquette, B., Leignel, V., Hardivillier, Y., Marcotte, I.,... Mouget, J.-L. (2014). Marennine, Promising Blue Pigments from a Widespread Haslea Diatom Species Complex. Marine Drugs, 12(6), 3161–3189. http://dx.doi.org/10.3390/md12063161.
  • Byette, F., Pellerin, C. et Marcotte, I. (2014). Self-assembled pH-responsive films prepared from mussel anchoring threads. Journal of Materials Chemistry B, 2(37), 6378–6386. http://dx.doi.org/10.1039/C4TB01021C.
  • Tardy-Laporte, C., Arnold, A.A., Génard, B., Gastineau, R., Morançais, M., Mouget, J.L.,.... Marcotte, I. (2013). A 2H solid-state NMR study of effect of antimicrobials on intact Escherichia coli without mutating. Biochimica et Biophysica Acta – Biomembranes, 1828(2), 614–622. http://dx.doi.org/10.1016/j.bbamem.2012.09.011.
  • Gravel, A., Arnold, A.A., Dufourc, E.J. et Marcotte, I. (2013). An NMR investigation of the structure, function and role of the hERG channel selectivity filter in the long QT syndrome. Biochimica et Biophysica Acta – Biomembranes, 1828(6), 1494–1502. http://dx.doi.org/10.1016/j.bbamem.2013.02.012.
  • Friddin, M.S., Smithers, N.P., Beaugrand, M., Marcotte, I., Williamson, P.T.F., Morgan, H. et de Planque, M.R.R. (2013). Single-channel electrophysiology of cell-free expressed ion channels by direct incorporation in lipid bilayers. Analyst, 138(24), 7294–7298. http://dx.doi.org/10.1039/C3AN01540H.
  • Arnold, A.A., Byette, F., Séguin-Heine, M.-O., LeBlanc, A., Sleno, L., Tremblay, R.,... Marcotte, I. (2013). Solid-state NMR structure determination of whole anchoring threads from the blue mussel Mytilus edulis. Biomacromolecules, 14(1), 132–141. http://dx.doi.org/10.1021/bm301493u.
  • Arnold, A.A., Terskikh, V., Naccache, R., Marcotte, I. et Capobianco, J.A. (2013). Structure of NaYF4 upconverting nanoparticles: a multinuclear solid-state NMR and DFT computational study. The Journal of Physical Chemistry C, 117(48), 25733–25741. http://dx.doi.org/10.1021/jp405813a.
  • Hennebicq, R., Fabra, G., Pellerin, C., Marcotte, I., Myrand, B. et Tremblay, R. (2013). The effect of spawning of cultured mussels (Mytilus edulis) on mechanical properties, chemical and biochemical composition of byssal threads. Aquaculture, 410-411, 11–17. http://dx.doi.org/10.1016/j.aquaculture.2013.06.011.
  • Brisebois, P.P., Arnold, A.A., Chabre, Y.M., Roy, R. et Marcotte, I. (2012). Comparative study of the interaction of fullerenol nanoparticles with eukaryotic and bacterial model membranes using solid-state NMR and FTIR spectroscopy. European Biophysics Journal, 41(6), 535–544. http://dx.doi.org/10.1007/s00249-012-0809-5.
  • Leblanc, A., Arnold, A.A., Nadalini, J.-B., Seguin-Heine, M.-O., Marcotte, I., Tremblay, R. et Sleno, L. (2012). Determination of isotopic labeling of proteins by precursor ion scanning liquid chromatography/tandem mass spectrometry of derivatized amino acids applied to nuclear magnetic resonance studies. Rapid Communications in Mass Spectrometry, 26(10), 1165–1174. http://dx.doi.org/10.1002/rcm.6204.
  • Nirasay, S., Badia, A., Leclair, G., Claverie, J.P. et Marcotte, I. (2012). Polydopamine-supported lipid bilayers. Materials, 5(12), 2621–2636. http://dx.doi.org/10.3390/ma5122621.
  • Lachance, A.-A., Hennebicq, R., Myrand, B., Sévigny J.-M., Kraffe, É., Marty, Y., Marcotte, I.,... Tremblay, R. (2011). Biochemical and genetic characteristics of suspension-cultured mussels (Mytilus edulis) in relation to byssal thread production and losses by fall-off. Aquatic Living Resource, 24(3), 283–293. http://dx.doi.org/10.1051/alr/2011115.
  • Byette, F., Bouchard, F., Pellerin, C., Paquin, J., Marcotte, I. et Mateescu, M.A. (2011). Cell-culture compatible silk fibroin scaffolds concomitantly patterned by freezing conditions and salt concentration. Polymer Bulletin, 67(1), 159–175. http://dx.doi.org/10.1007/s00289-010-0438-z.
  • Warschawski, D.E., Arnold, A.A., Beaugrand, M., Gravel, A., Chartrand, E. et Marcotte, I. (2011). Choosing membrane mimetics for NMR structural studies of transmembrane proteins. Biochimica et Biophysica Acta – Biomembranes, 1808(8), 1957–1974. http://dx.doi.org/10.1016/j.bbamem.2011.03.016.
  • Chabre, Y., Brisebois, P., Abbasi, L., Kerr, S.C., Fahy, J.V., Marcotte, I. et Roy, R. (2011). Hexaphenylbenzene as a Rigid Template for the Straightforward Syntheses of "Star-Shaped" Glycodendrimers. Journal of Organic Chemistry, 76(2), 724–727. http://dx.doi.org/10.1021/jo102215y.
  • Nirasay, S., Mouget, Y., Marcotte, I. et Claverie J. P. (2011). Supported bilayer on a nanopatterned membrane as model PAMPA membranes. International Journal of Pharmaceutics, 421(1), 170–175. http://dx.doi.org/10.1016/j.ijpharm.2011.09.013.
  • Larocque, G., Arnold, A.A., Chartrand, É., Mouget, Y. et Marcotte, I. (2010). Effect of Sodium Bicarbonate as a Pharmaceutical Formulation Excipient on the Interaction of Fluvastatin with Membrane Phospholipids. European Biophysics Journal, 39(12), 1637–1647. http://dx.doi.org/10.1007/s00249-010-0622-y.
  • Chartrand, É., Arnold, A.A., Gravel, A., Jenna, S. et Marcotte, I. (2010). Potential role of the membrane in the hERG channel functioning and drug-induced long QT syndrome. Biochimica et Biophysica Acta – Biomembranes, 1798(9), 1651–1662. http://dx.doi.org/10.1016/j.bbamem.2010.05.019.
  • Arnold, A.A. et Marcotte, I. (2009). Studying natural structural protein fibers by solid-state nuclear magnetic resonance. Concepts in Magnetic Resonance: Part A, 34A(1), 24–47. http://dx.doi.org/10.1002/cmr.a.20132.
  • Marcotte, I., Van Beek, J.D. et Meier, B.H. (2007). Molecular order and structure of spider dragline silk investigated by two-dimensional solid-state NMR spectroscopy. Macromolecules, 40(26), 1995–2001. http://dx.doi.org/10.1021/ma062452n.
  • Marcotte, I., Belanger, A. et Auger, M. (2006). The orientation effect of gramicidin A on bicelles and Eu3+-doped bicelles as studied by solid-state NMR and FTIR spectroscopy. Chemistry and Physics of Lipids, 139(2), 137–149. http://dx.doi.org/10.1016/j.chemphyslip.2005.12.002.
  • Marcotte, I. et Auger, M. (2005). Bicelles as model membranes for solid- and solution-state NMR studies of membrane peptides and proteins. Concepts in Magnetic Resonance: Part A, 24A(1), 17–37. http://dx.doi.org/10.1002/cmr.a.20025.
  • Marcotte, I., Auger, M., Separovic, F. et Gagné, S.M. (2004). A Multidimensional 1H NMR Investigation of the Conformation of Methionine-Enkephalin in Fast-Tumbling Bicelles. Biophysical Journal, 86(3), 1587–1600. http://dx.doi.org/10.1016/S0006-3495(04)74226-5.
  • Marcotte, I., Ouellet, M. et Auger, M. (2004). Insights on the Interaction of Met-Enkephalin with Negatively Charged Membranes: an Infrared and Solid-Sate NMR Spectroscopic Study. Chemistry and Physics of Lipids, 127(2), 175–187. http://dx.doi.org/10.1016/j.chemphyslip.2003.10.012.
  • Marcotte, I., Wegener, K., Lam, Y.-H., Chia, B.S.C., de Planque, M.R.R., Bowie, J.H.,... Separovic, F. (2003). Interaction of Antimicrobial Peptides from Australian Amphibians with Lipid Membranes. Chemistry and Physics of Lipids, 122(1-2), 107–120. http://dx.doi.org/10.1016/S0009-3084(02)00182-2.
  • Marcotte, I., Dufourc, E.J., Ouellet, M. et Auger, M. (2003). Interaction of the Neuropeptide Met-Enkephalin with Zwitterionic and Negatively Charged Bicelles as Viewed by 31P and 2H Solid-State NMR. Biophysical Journal, 85(1), 328–339. http://dx.doi.org/10.1016/S0006-3495(03)74477-4.
  • Paul, G.J.C., Marcotte, I., Anastassopoulou, J., Arkas, M., Paleos, C.M. et Bertrand, M.J. (1996). An investigation of the clustering processes occurring in liquid-assisted secondary ion mass spectrometry for alkyl quaternary ammonium bromides. Journal of Mass Spectrometry, 31(1), 95–100. http://dx.doi.org/10.1002/(SICI)1096-9888(199601)31:1<95::AID-JMS275>3.0.CO;2-V.
Chapitres de livre
  • Marcotte, I. et Booth, V. (2014). 2H solid-state NMR study of peptide-membrane interactions in intact bacteria. Dans F. Separovic et A. Naito (dir.). Advances in Biological Solid-State NMR: Proteins and Membrane-Active Peptides (p. 459–475). Cambridge : Royal Society of Chemistry.
    Notes: collection New Developments in NMR
  • Lefèvre, T., Byette, F., Marcotte, I. et Auger, M. (2014). Protein- and peptide-based materials: a source of inspiration for innovation. Dans R. Gauvin et M. Leclerc (dir.). Functional materials for energy, sustainable development and biomedical sciences (p. 415–442). Berlin : De Gruyter.